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J-GLOBAL ID：202002282506549419   Reference number：20A0481109

A FLCN-TFE3 Feedback Loop Prevents Excessive Glycogenesis and Phagocyte Activation by Regulating Lysosome Activity

FLCN-TFE3フィードバックループはリソソーム活性を調節することにより過剰な糖生成と食細胞活性化を妨げる【JST・京大機械翻訳】

Author (21)： Endoh Mitsuhiro (Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, Singapore 117599, Singapore) ,  Endoh Mitsuhiro (International Research Center for Medical Sciences (IRCMS), Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan) ,  Endoh Mitsuhiro (Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan) ,  Baba Masaya (International Research Center for Medical Sciences (IRCMS), Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan) ,  Baba Masaya (Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA) ,  Endoh Tamie (Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, Singapore 117599, Singapore) ,  Endoh Tamie (International Research Center for Medical Sciences (IRCMS), Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan) ,  Endoh Tamie (Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan) ,  Hirayama Akiyoshi (Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata 997-0052, Japan) ,  Nakamura-Ishizu Ayako (Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, Singapore 117599, Singapore) ,  Nakamura-Ishizu Ayako (International Research Center for Medical Sciences (IRCMS), Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan) ,  Umemoto Terumasa (International Research Center for Medical Sciences (IRCMS), Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan) ,  Hashimoto Michihiro (International Research Center for Medical Sciences (IRCMS), Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan) ,  Nagashima Kunio (Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA) ,  Soga Tomoyoshi (Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata 997-0052, Japan) ,  Lang Martin (Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA) ,  Schmidt Laura S. (Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA) ,  Schmidt Laura S. (Basic Science Program, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, MD 21702, USA) ,  Linehan W. Marston (Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA) ,  Suda Toshio (Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, Singapore 117599, Singapore) ,  Suda Toshio (International Research Center for Medical Sciences (IRCMS), Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan)
Material： Cell Reports
Volume： 30  Issue： 6  Page： 1823-1834.e5  Publication year： 2020 
JST Material Number： W3124A  ISSN： 2211-1247  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The tumor suppressor folliculi...

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Thesaurus term： vacuole ,  Mammalia ,  variable resistor ,  knockout mouse ,  biosynthesis ,  cytoplasm ,  gene ,  gluconeogenesis ,  phenotype ,  glycogen ,  transcription factor ,  *lysosome ,  glycosylation ,  ovarian follicle ,  *phagocyte

Author keywords (8)： Lysosome ,  Lysosomal storage disease ,  glycogen ,  glycogenesis ,  gluconeogenesis ,  Birt-Hogg-Dube Syndrome ,  Folliculin ,  hemophagocytosis

JST classification (3)： Gene expression  (EC02040Q) ,  Biological function  (EB03040U) ,  Cell physiology in general  (EF02010S)

Terms in the title (9)： FLCN ,  TFE3 ,  フィードバックループ ,  リソソーム ,  活性 ,  調節 ,  糖 ,  食細胞 ,  活性化