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J-GLOBAL ID：202002282595569294   Reference number：20A0363938

Increased expression of prion protein gene is accompanied by demethylation of CpG sites in a mouse embryonal carcinoma cell line, P19C6

プリオン蛋白質遺伝子の増加発現は,マウス胚性癌細胞ライン(P19C6)で,CpG部位の脱メチル化を伴う

Author (5)： DALAI Wuyun (Kobe Univ., Hyogo, JPN) ,  MATSUO Eiko (Kobe Univ., Hyogo, JPN) ,  TAKEYAMA Natsumi (Nippon Inst. Biological Sci., Tokyo, JPN) ,  KAWANO Junichi (Kobe Univ., Hyogo, JPN) ,  SAEKI Keiichi (Kobe Univ., Hyogo, JPN)
Material： Journal of Veterinary Medical Science (Web)
Volume： 79  Issue： 3  Page： 644-648(J-STAGE)  Publication year： 2017 
JST Material Number： U1094A  ISSN： 1347-7439  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *gene ,...
Semi thesaurus term： *prion protein gene ,...

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JST classification (4)： Research and development  (FA01030T) ,  Laboratry organisms  (EA03070Y) ,  Gene expression  (EC02040Q) ,  Basic oncology in general  (GE02010R)

Reference (21)：

• 1. Aran, D. and Hellman, A. 2013. DNA methylation of transcriptional enhancers and cancer predisposition. Cell 154: 11-13.
• 2. Baybutt, H. and Manson, J. 1997. Characterisation of two promoters for prion protein (PrP) gene expression in neuronal cells. Gene 184: 125-131.
• 3. Brueckner, B., Garcia Boy, R., Siedlecki, P., Musch, T., Kliem, H. C., Zielenkiewicz, P., Suhai, S., Wiessler, M. and Lyko, F. 2005. Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases. Cancer Res. 65: 6305-6311.
• 4. Butler, D. A., Scott, M. R., Bockman, J. M., Borchelt, D. R., Taraboulos, A., Hsiao, K. K., Kingsbury, D. T. and Prusiner, S. B. 1988. Scrapie-infected murine neuroblastoma cells produce protease-resistant prion proteins. J. Virol. 62: 1558-1564.
• 5. Cabral, A. L., Lee, K. S. and Martins, V. R. 2002. Regulation of the cellular prion protein gene expression depends on chromatin conformation. J. Biol. Chem. 277: 5675-5682.

Terms in the title (6)： プリオン蛋白質遺伝子 ,  発現 ,  マウス ,  胚性癌細胞 ,  CPG ,  脱メチル化