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J-GLOBAL ID：202002282842138405   Reference number：20A1082457

A novel Golgi mannosidase inhibitor: Molecular design, synthesis, enzyme inhibition, and inhibition of spheroid formation

新しいゴルジのマンノシダーゼ阻害剤:分子設計,合成,酵素阻害,およびスフェロイド形成の阻害【JST・京大機械翻訳】

Author (9)： Koyama Ryosuke (Department of Chemistry and Life Science, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880, Japan) ,  Kano Yui (Department of Chemistry and Life Science, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880, Japan) ,  Kikushima Kaori (Department of Chemistry and Life Science, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880, Japan) ,  Mizutani Ayaka (Department of Chemistry and Life Science, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880, Japan) ,  Soeda Yuta (Department of Chemistry and Life Science, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880, Japan) ,  Miura Kazuki (Department of Chemistry and Life Science, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880, Japan) ,  Hirano Takako (Department of Chemistry and Life Science, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880, Japan) ,  Nishio Toshiyuki (Department of Chemistry and Life Science, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880, Japan) ,  Hakamata Wataru (Department of Chemistry and Life Science, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880, Japan)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 28  Issue： 11  Page： Null  Publication year： 2020 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Effective chemotherapy for sol...

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Thesaurus term： antitumor drug ,  *enzyme inhibition ,  tumor ,  tumor cell ,  protein ,  human(primates) ,  drug therapy ,  *mannosidase ,  *molecular design
Semi thesaurus term： 化合物ライブラリー ,  固形癌 ,  N-グリカン ,  細胞表面 ,  *スフェロイド ,  阻害活性 , 【Automatic Indexing@JST】

Author keywords (5)： Golgi mannosidase ,  Non-sugar mimic inhibitor ,  Cancer stem cell ,  Cell-cell communication ,  Spheroid formation

JST classification (5)： Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Polysaccharides  (CF10054P) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Enzyme in general  (EB09010D) ,  Structure-activity relationship of drugs  (GV01050B)

Terms in the title (6)： マンノシダーゼ ,  阻害剤 ,  分子設計 ,  酵素阻害 ,  スフェロイド ,  阻害