Art

J-GLOBAL ID：202002282872278190   Reference number：20A0477357

HPLC-MS/MS method for the determination and pharmacokinetic study of six compounds against rheumatoid arthritis in rat plasma after oral administration of the extract of Caulophyllum robustum Maxim

Caulophyllum robustum Maximの抽出物の経口投与後のラット血漿中の関節リウマチに対する6種の化合物の定量と薬物動態研究のためのHPLC-MS/MS法【JST・京大機械翻訳】

Author (8)： Guo Yuyan (Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Harbin 150040, China) ,  lue Shaowa (Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Harbin 150040, China) ,  Yang Bingyou (Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Harbin 150040, China) ,  Li Guoyu (Pharmaceutical College, Harbin University of Commerce, Harbin 150086, China) ,  Ma Wenbao (Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Harbin 150040, China) ,  Guo Qiaoxin (Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Harbin 150040, China) ,  Wang Qiuhong (Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Harbin 150040, China) ,  Kuang Haixue (Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Harbin 150040, China)
Material： Journal of Pharmaceutical and Biomedical Analysis  (J Pharm Biomed Anal)
Volume： 181  Page： Null  Publication year： 2020 
JST Material Number： H0876A  ISSN： 0731-7085  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Caulophyllum robustum Maxim (C...

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Thesaurus term： *plasma(blood) ,  electrospray ionization ,  Chinese drug ,  *rat ,  flow velocity ,  correlation coefficient ,  *rheumatoid arthritis ,  mobile phase ,  chromatography ,  saponin ,  high performance liquid chromatography ,  matrix effect ,  gradient elution ,  alkaloid ,  rhizome

Author keywords (5)： Caulophyllum robustum Maxim ,  Pharmacokinetics ,  triterpenoids ,  alkaloid ,  HPLC-MS/MS

JST classification (2)： Basic biopharmacy  (GY01021U) ,  Analysis of drugs  (GV01040Q)

Terms in the title (10)： 抽出物 ,  経口投与 ,  ラット ,  血漿 ,  関節リウマチ ,  定量 ,  薬物動態 ,  研究 ,  HPLC ,  MS法