Art

J-GLOBAL ID：202002283401155363   Reference number：20A0637128

Osteonecrosis of the Jaw during Lenvatinib Therapy: A Case Report Based on Surgical Management

レンバチニブ療法中の顎骨壊死:外科的管理に基づく症例報告

Author (8)： Udagawa Gen (Department of Dentistry and Oral Surgery, Tokyo Women’s Medical University Yachiyo Medical Center) ,  Udagawa Gen (Department of Oral and Maxillofacial Surgery, School of Medicine, Tokyo Women’s Medical University) ,  Okamoto Toshihiro (Department of Dentistry and Oral Surgery, Tokyo Women’s Medical University Yachiyo Medical Center) ,  Okamoto Toshihiro (Department of Oral and Maxillofacial Surgery, School of Medicine, Tokyo Women’s Medical University) ,  Kaibuchi Nobuyuki (Department of Oral and Maxillofacial Surgery, School of Medicine, Tokyo Women’s Medical University) ,  Sangu Noriko (Department of Oral and Maxillofacial Surgery, School of Medicine, Tokyo Women’s Medical University) ,  Kagawa Chie (Department of Oral and Maxillofacial Surgery, School of Medicine, Tokyo Women’s Medical University) ,  Ando Tomohiro (Department of Oral and Maxillofacial Surgery, School of Medicine, Tokyo Women’s Medical University)
Material： Tokyo Women's Medical University Journal (Web)
Volume： 3  Page： 78-82(J-STAGE)  Publication year： 2019 
JST Material Number： U1328A  ISSN： 2432-6186  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： Follicular carcinoma of thyroid ,...

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Author keywords (4)： MRONJ ,  lenvatinib ,  antiangiogenic drug ,  drug holiday

JST classification (4)： Clinical application of antitumor(=antineoplastic)drugs  (GW16020L) ,  Tumors(=neoplasms)of endocrine system  (GL04000P) ,  Diseases of tooth and mouth(=oral cavity)  (GT03000G) ,  Drug therapy(=pharmacotherapy)for tumors  (GE03032C)

Substance index (1)： E-7080

Reference (15)：

• 1) Tohyama O, Matsui J, Kodama K et al: Antitumor activity of lenvatinib (e7080): an angiogenesis inhibitor that targets multiple receptor tyrosine kinases in preclinical human thyroid cancer models. J Thyroid Res 2014: 638747, 2014
• 2) Yamamoto Y, Matsui J, Matsushima T et al: Lenvatinib, an angiogenesis inhibitor targeting VEGFR/FGFR, shows broad antitumor activity in human tumor xenograft models associated with microvessel density and pericyte coverage. Vasc Cell 6: 18, 2014
• 3) Marx RE: Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg 61: 1115-1117, 2003
• 4) Aghaloo TL, Felsenfeld AL, Tetradis S: Osteonecrosis of the jaw in a patient on denosumab. J Oral Maxillofac Surg 68: 959-963, 2010
• 5) Baron R, Ferrari S, Russell RG: Denosumab and bisphosphonates: different mechanisms of action and effects. Bone 48: 677-692, 2011

Terms in the title (5)： レンバチニブ ,  療法 ,  顎骨壊死 ,  外科 ,  症例報告