Art

J-GLOBAL ID：202002283484776797   Reference number：20A2716858

Tocilizumab monotherapy uncovered the role of the CCL22/17-CCR4⁺ Treg axis during remission of crescentic glomerulonephritis

トシリズマブ単独療法は半月性糸球体腎炎の寛解時のCCL22/17-CCR4+Treg軸の役割を明らかにする【JST・京大機械翻訳】

Author (11)： Sakai Ryota (Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan) ,  Sakai Ryota (Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan) ,  Ito Minako (Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan) ,  Yoshimoto Keiko (Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan) ,  Chikuma Shunsuke (Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan) ,  Kurasawa Takahiko (Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan) ,  Kondo Tsuneo (Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan) ,  Suzuki Katsuya (Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan) ,  Takeuchi Tsutomu (Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan) ,  Amano Koichi (Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan) ,  Yoshimura Akihiko (Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan)
Material： Clinical & Translational Immunology
Volume： 9  Issue： 11  Page： e1203  Publication year： 2020 
JST Material Number： W3668A  ISSN： 2050-0068  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： OBJECTIVES: Tocilizumab (TCZ) ...

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Thesaurus term： serum ,  human(primates) ,  lymph node ,  serum concentration ,  autoimmunity ,  macrophage ,  interleukin ,  monoclonal antibody ,  autoimmune disease ,  *remission ,  ANCA ,  chemokine ,  *regulatory T cell
Semi thesaurus term： FoxP3 ,  *トシリズマブ , 【Automatic Indexing@JST】

Author keywords (7)： ANCA-associated vasculitis ,  crescentic glomerulonephritis ,  CCL22/17-CCR4 axis ,  IL-6 ,  M2-like type macrophages ,  tocilizumab ,  Tregs

JST classification (2)： Basic research of immunotherapeutic agents and blood preparations  (GW22010D) ,  Immunologic diseases,allergic diseases in general.  (GD04010C)

Terms in the title (6)： トシリズマブ ,  単独療法 ,  糸球体腎炎 ,  寛解 ,  CCL22 ,  役割