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J-GLOBAL ID：202002284265040333   Reference number：20A1203340

Developing spray-freeze-dried particles containing a hyaluronic acid-coated liposome-protamine-DNA complex for pulmonary inhalation

肺吸入のためのヒアルロン酸被覆リポソーム-プロタミン-DNA複合体を含む噴霧凍結乾燥粒子の開発【JST・京大機械翻訳】

Author (11)： Fukushige Kaori (Department of Anatomy, School of Medicine, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan) ,  Fukushige Kaori (Drug Delivery and Nano Pharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan) ,  Tagami Tatsuaki (Drug Delivery and Nano Pharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan) ,  Naito Munekazu (Department of Anatomy, School of Medicine, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan) ,  Goto Eiichi (Drug Delivery and Nano Pharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan) ,  Hirai Shuichi (Department of Anatomy, School of Medicine, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan) ,  Hatayama Naoyuki (Department of Anatomy, School of Medicine, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan) ,  Yokota Hiroki (Department of Anatomy, School of Medicine, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan) ,  Yasui Takao (Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8603, Japan) ,  Baba Yoshinobu (Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8603, Japan) ,  Ozeki Tetsuya (Drug Delivery and Nano Pharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan)
Material： International Journal of Pharmaceutics  (Int J Pharm)
Volume： 583  Page： Null  Publication year： 2020 
JST Material Number： A0285B  ISSN： 0378-5173  CODEN： IJPHD  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The liposome-protamine-DNA com...

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Thesaurus term： *covering ,  *DNA ,  *inhalation ,  *hyaluronic acid ,  human(primates) ,  *protamine ,  *complex(substance) ,  *liposome ,  cytotoxicity ,  in vitro experiment ,  A549 cell ,  siRNA ,  gene silencing
Semi thesaurus term： プラスミドDNA ,  *DNA複合体 , 【Automatic Indexing@JST】

Author keywords (6)： Liposome-protamine-DNA complex (LPD) ,  Hyaluronic acid ,  Spray-freeze-drying ,  Small interfering RNA (siRNA) ,  Lipid nanoparticle ,  Nanoparticles-in-microparticles

JST classification (2)： Basic biopharmacy  (GY01021U) ,  Gene manipulation  (EC02050B)

Terms in the title (8)： 肺 ,  吸入 ,  ヒアルロン酸 ,  リポソーム ,  プロタミン ,  DNA複合体 ,  噴霧凍結 ,  開発