Art

J-GLOBAL ID：202002284705115955   Reference number：20A2656828

Structural basis for producing selective MAP2K7 inhibitors

選択的MAP2K7阻害剤を生産するための構造的基礎【JST・京大機械翻訳】

Author (5)： Murakawa Yuka (Graduate School of Science, Osaka Prefecture University, Osaka 599-8531, Japan) ,  Valter Shirly (Whol Institute for Drug Discovery of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, The Weizmann Institute of Science, Rehovot 7610001, Israel) ,  Barr Haim (Whol Institute for Drug Discovery of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, The Weizmann Institute of Science, Rehovot 7610001, Israel) ,  London Nir (Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel) ,  Kinoshita Takayoshi (Graduate School of Science, Osaka Prefecture University, Osaka 599-8531, Japan)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 30  Issue： 22  Page： Null  Publication year： 2020 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Mitogen-activated protein kina...

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Thesaurus term： crystal structure ,  complex (substance) ,  covalent bond ,  *electrophilic reagent ,  MAP kinase kinase ,  Drug Discovery ,  kinase ,  Drug target ,  aliphatic carboxylic acid ,  carboxamide ,  vinyl compound ,  unsaturated carboxylic acid

Author keywords (4)： MAP2K7 ,  Covalent bonding inhibitor ,  Structural flexibility ,  Selectivity

JST classification (2)： Enzyme in general  (EB09010D) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Substance index (1)： Acrylamide

Terms in the title (2)： 阻害剤 ,  基礎