Art

J-GLOBAL ID：202002284714544064   Reference number：20A1015099

An in vitro toolbox to accelerate anti-malarial drug discovery and development

抗マラリア薬発見と開発を加速するためのin vitroツールボックス【JST・京大機械翻訳】

Author (23)： Charman Susan A. (Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia) ,  Andreu Alice (Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia) ,  Barker Helena (Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia) ,  Blundell Scott (Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia) ,  Campbell Anna (Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia) ,  Campbell Michael (Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia) ,  Chen Gong (Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia) ,  Chiu Francis C. K. (Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia) ,  Crighton Elly (Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia) ,  Katneni Kasiram (Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia) ,  Morizzi Julia (Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia) ,  Patil Rahul (Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia) ,  Pham Thao (Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia) ,  Ryan Eileen (Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia) ,  Saunders Jessica (Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia) ,  Shackleford David M. (Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia) ,  White Karen L. (Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia) ,  Almond Lisa (Certara UK Limited, Simcyp Division, Sheffield, UK) ,  Dickins Maurice (Certara UK Limited, Simcyp Division, Sheffield, UK) ,  Smith Dennis A. (4 The Maltings, Kent, UK) ,  Moehrle Joerg J. (Medicines for Malaria Venture, Geneva 15, Switzerland) ,  Burrows Jeremy N. (Medicines for Malaria Venture, Geneva 15, Switzerland) ,  Abla Nada (Medicines for Malaria Venture, Geneva 15, Switzerland)
Material： Malaria Journal (Web)
Volume： 19  Issue： 1  Page： 1-27  Publication year： 2020 
JST Material Number： U7332A  ISSN： 1475-2875  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Modelling and simulation are b...

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Thesaurus term： solubility(ratio) ,  standardization ,  plasma(blood) ,  substrate(biochemistry) ,  clearance ,  *antimalarial drug ,  human(primates) ,  *malaria ,  drug interaction ,  medium ,  cytochrome P450 ,  microsome ,  ultracentrifugation ,  *in vitro experiment ,  Caco2 cell

Author keywords (9)： Physiologically-based pharmacokinetic modelling ,  Anti-malarial drugs ,  Ionization constant ,  Partition coefficient ,  Biorelevant solubility ,  Protein binding ,  Blood to plasma partitioning ,  Microsomal stability ,  CYP inhibition

JST classification (1)： Basic biopharmacy  (GY01021U)

Reference (85)：

• World malaria report 2015; 2015; CR1; citation_publisher=World Health Organization
• World malaria report 2018; 2018; CR2; citation_publisher=World Health Organization
• Lancet; The global fight against malaria is at crossroads; P Alonso, AM Noor; 390; 2017; 2532-2534; 10.1016/S0140-6736(17)33080-5; citation_id=CR3
• Nat Rev Drug Discov.; Malaria medicines: a glass half full?; TN Wells, R Hooft van Huijsduijnen, WC Van Voorhis; 14; 2015; 424-442; 10.1038/nrd4573; citation_id=CR4
• Curr Pharmacol Rep.; Recent advances in development and application of physiologically-based pharmacokinetic (PBPK) models: a transition from academic curiosity to regulatory acceptance; M Jamei; 2; 2016; 161-169; 10.1007/s40495-016-0059-9; citation_id=CR5

Terms in the title (5)： 抗マラリア薬 ,  発見 ,  開発 ,  加速 ,  ツールボックス