Art

J-GLOBAL ID：202002285128972602   Reference number：20A0749807

Efficient Synthesis of Marine Alkaloid Ageladine A and its Structural Modification for Exploring New Biological Activity

海産天然物ageladine Aの効率合成を基盤とした構造展開と新規活性探索

Author (4)： IWATA TAKAYUKI ,  FUKASE KOICHI ,  NAKAO YOICHI ,  TANAKA KATSUNORI (理化学研究所開拓研究本部田中生体機能合成化学研究室)
Material： 有機合成化学協会誌  (Journal of Synthetic Organic Chemistry, Japan)
Volume： 78  Issue： 1  Page： 51-59(J-STAGE)  Publication year： 2020 
JST Material Number： F0383A  ISSN： 0037-9980  CODEN： YGKKAE  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： one-pot synthesis ,...
Semi thesaurus term： Agelas nakamurai ,...

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Author keywords (6)： structural modification ,  marine alkaloid ,  2-aminoimidazoles ,  one-pot synthesis ,  bio-inspired reaction ,  neuronal differentiation modulator

JST classification (2)： Alkaloids  (CF10030D) ,  Cell physiology in general  (EF02010S)

Substance index (17)： 1-(1H-indol-6-yl)-4-(pyridin-2-yl)imidazo[4,5-c]pyridin-2-amine ,  1-(2,4-dimethoxyphenyl)-4-(pyridin-2-yl)imidazo[4,5-c]pyridin-2-amine ,  4-(pyridin-2-yl)-1-(3,4,5-trimethoxyphenyl)imidazo[4,5-c]pyridin-2-amine ,  1-(3,4-Dimethoxyphenyl)-4-(2-pyridinyl)-1H-imidazo[4,5-c]pyridine-2-amine ,  4-(4,5-dibromo-1H-pyrrol-2-yl)-1-(3,4-dimethoxyphenyl)imidazo[4,5-c]pyridin-2-amine ,  1-(3,4-dimethoxyphenyl)-4-[6-(trifluoromethyl)pyridin-2-yl]imidazo[4,5-c]pyridin-2-amine ,  1-(4-tert-butylphenyl)-4-(pyridin-2-yl)imidazo[4,5-c]pyridin-2-amine ,  1-(4-fluorophenyl)-4-(pyridin-2-yl)imidazo[4,5-c]pyridin-2-amine ,  1-(4-methoxyphenyl)-4-(pyridin-2-yl)imidazo[4,5-c]pyridin-2-amine ,  1-(naphthalen-1-yl)-4-(pyridin-2-yl)imidazo[4,5-c]pyridin-2-amine ,  4-(pyridin-2-yl)-1-[4-(trifluoromethyl)phenyl]imidazo[4,5-c]pyridin-2-amine ,  1-Phenyl-4-(2-pyridinyl)-1H-imidazo[4,5-c]pyridine-2-amine ,  4-(2-Pyridyl)-1H-imidazo[4,5-c]pyridine-2-amine ,  4-[2-amino-4-(pyridin-2-yl)imidazo[4,5-c]pyridin-1-yl]phenol ,  Ageladine A ,  Harmine ,  methyl (2S)-5-[2-amino-4-(pyridin-2-yl)imidazo[4,5-c]pyridin-1-yl]-2-acetamidopentanoate

Reference (79)：

• 1) (a) D. J. Newman, G. M. Cragg, J. Nat. Prod., 75, 311 (2012)
• (b) J. W.-H. Li, J. C. Vederas, Science, 325, 161 (2009)
• 2) O. Sticher, Nat. Prod. Rep., 25, 517 (2008)
• 3) F. E. Koehn, High impact technologies for natural products screening, in Natural Compounds as Drugs, Vol. I, eds. by F. Petersem, R. Amstutz, Birkhäuser Basel, Basel, pp 175-210 (2008)
• 4) B. Wilkinson, J. Micklefield, Nat. Chem. Biol., 3, 379 (2007)

Terms in the title (5)： 天然物 ,  基盤 ,  構造展開 ,  活性 ,  探索