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J-GLOBAL ID：202002285130393537   Reference number：20A1608128

Interaction between Angiotensin Receptor and β-Adrenergic Receptor Regulates the Production of Amyloid β-Protein

アンギオテンシン受容体とβ-アドレナリン受容体との間の相互作用はアミロイドβ蛋白質の産生を調節する

Author (15)： Kikuchi Kota (Division of Neuroscience, Department of Biological Pharmacy, School of Pharmacy, Iwate Medical University) ,  Kikuchi Kota (Department of Pharmacy, Japanese Red Cross Morioka Hospital) ,  Fujita Yu (Division of Neuroscience, Department of Biological Pharmacy, School of Pharmacy, Iwate Medical University) ,  Shen Xuefeng (Division of Neuroscience, Department of Biological Pharmacy, School of Pharmacy, Iwate Medical University) ,  Liu Junjun (Division of Neuroscience, Department of Biological Pharmacy, School of Pharmacy, Iwate Medical University) ,  Terakawa Tomoki (Division of Neuroscience, Department of Biological Pharmacy, School of Pharmacy, Iwate Medical University) ,  Nishikata Daiki (Division of Neuroscience, Department of Biological Pharmacy, School of Pharmacy, Iwate Medical University) ,  Niibori Sho (Division of Neuroscience, Department of Biological Pharmacy, School of Pharmacy, Iwate Medical University) ,  Ito Takayuki (Division of Neuroscience, Department of Biological Pharmacy, School of Pharmacy, Iwate Medical University) ,  Ashidate Kazuyuki (Division of Neuroscience, Department of Biological Pharmacy, School of Pharmacy, Iwate Medical University) ,  Kikuchi Takuya (Division of Neuroscience, Department of Biological Pharmacy, School of Pharmacy, Iwate Medical University) ,  Kikuchi Yu (Division of Neuroscience, Department of Biological Pharmacy, School of Pharmacy, Iwate Medical University) ,  Maeda Tomoji (Department of Pharmacology, Nihon Pharmaceutical University) ,  Zou Kun (Department of Biochemistry, School of Medicine, Nagoya City University) ,  Komano Hiroto (Division of Neuroscience, Department of Biological Pharmacy, School of Pharmacy, Iwate Medical University)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 43  Issue： 4  Page： 731-735(J-STAGE)  Publication year： 2020 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： mouse(animal) ,...
Semi thesaurus term： *Receptors, Adrenergic, beta-2 ,...

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Author keywords (8)： Alzheimer’s disease ,  amyloid β-protein ,  angiotensin receptor ,  adrenergic receptor ,  Alzheimer’s disease ,  amyloid β-protein ,  angiotensin receptor ,  adrenergic receptor

JST classification (4)： Biological function  (EB03040U) ,  Cell physiology in general  (EF02010S) ,  Gene expression  (EC02040Q) ,  Basic neurology  (GN01020W)

Substance index (1)： Telmisartan

Reference (27)：

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• 3) Liu J, Liu S, Matsumoto Y, Murakami S, Sugakawa Y, Kami A, Tanabe C, Maeda T, Michikawa M, Komano H, Zou K. Angiotensin type 1a receptor deficiency decreases amyloid β-protein generation and ameliorates brain amyloid pathology. Sci. Rep., 5, 12059 (2015).
• 4) Liu J, Liu S, Tanabe C, Maeda T, Zou K, Komano H. Differential effects of angiotensin II receptor blockers on Aβ generation. Neurosci. Lett., 567, 51-56 (2014).
• 5) Ni Y, Zhao X, Bao G, Zou L, Teng L, Wang Z, Song M, Xiong J, Bai Y, Pei G. Activation of β₂-adrenergic receptor stimulates γ-secretase activity and accelerates amyloid plaque formation. Nat. Med., 12, 1390-1396 (2006).

Terms in the title (5)： アンギオテンシン受容体 ,  β-アドレナリン受容体 ,  相互作用 ,  アミロイドβ蛋白質 ,  調節