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J-GLOBAL ID：202002285704854194   Reference number：20A1336219

Inhibitory Effects of Indirubin-3′-oxime Derivatives on Lipid Accumulation in 3T3-L1 Cells

3T3-L1細胞における脂質蓄積に対するインジルビン-3′-オキシム誘導体の阻害作用

Author (5)： Nobushi Yasuhito (School of Pharmacy, Nihon University) ,  Saito Hiroaki (School of Pharmacy, Nihon University) ,  Miyairi Shinichi (School of Pharmacy, Nihon University) ,  Uchiyama Taketo (School of Pharmacy, Nihon University) ,  Kishikawa Yukinaga (School of Pharmacy, Nihon University)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 43  Issue： 3  Page： 503-508(J-STAGE)  Publication year： 2020 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： fat cell ,...
Semi thesaurus term： 3T3-L1 ,...

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Author keywords (8)： indirubin-3′-oxime derivative ,  3T3-L1 cell ,  obesity ,  lipid accumulation ,  indirubin-3′-oxime derivative ,  3T3-L1 cell ,  obesity ,  lipid accumulation

JST classification (2)： Clinical application of crude drugs  (GX06030U) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J)

Substance index (9)： 5′-Bromoindirubin-3′-oxime ,  5′-Methoxyindirubin-3′-oxime ,  6-Methoxyindirubin-3′-oxime ,  E-728 ,  6-Bromoindirubin-3-oxime ,  6-Bromoindirubin-3'-oxime ,  7-Bromoindirubin-3′-oxime ,  7-Methoxyindirbin 3-oxime ,  Indirubin 3'-oxime

Reference (33)：

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• 3) Formiguera X, Canton A. Obesity: epidemiology and clinical aspects. Best Pract. Res. Clin. Gastroenterol., 18, 1125-1146 (2004).
• 4) Mann CC. Public health. Provocative study says obesity may reduce U.S. life expectancy. Science, 307, 1716-1717 (2005).
• 5) Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature, 444, 840-846 (2006).

Terms in the title (6)： 3T3-L1細胞 ,  脂質蓄積 ,  インジルビン ,  オキシム ,  誘導体 ,  阻害作用