Art

J-GLOBAL ID：202002285732248671   Reference number：20A1336218

Effects of Catecholamine Metabolites on Beta-Adrenoceptor-Mediated Relaxation of Smooth Muscle: Evaluation in Mouse and Guinea-Pig Trachea and Rat Aorta

平滑筋のβアドレナリン受容体媒介弛緩に対するカテコールアミン代謝産物の影響:マウスおよびモルモットの気管とラット大動脈における評価

Author (7)： Yamaki Fumiko (Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University) ,  Koike Anna (Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University) ,  Kono Hikari (Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University) ,  Zhang Xiaoyue (Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University) ,  Yoshioka Kento (Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University) ,  Obara Keisuke (Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University) ,  Tanaka Yoshio (Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 43  Issue： 3  Page： 493-502(J-STAGE)  Publication year： 2020 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *smooth muscle ,...

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Author keywords (12)： metadrenaline ,  normetadrenaline ,  34-dihydroxyphenylglycol ,  β-adrenoceptor ,  tracheal relaxation ,  aortic relaxation ,  metadrenaline ,  normetadrenaline ,  34-dihydroxyphenylglycol ,  β-adrenoceptor ,  tracheal relaxation ,  aortic relaxation

JST classification (2)： Basic medicine on musculoskeletal system  (GG01020B) ,  Muscles  (EJ10020G)

Substance index (9)： 3,4-Dihydroxyphenylglycol ,  3,4-Dihydroxymandelic acid ,  3,5-Dinitropyrocatechol ,  CGP-12177A ,  Metanephrine ,  Normetanephrine ,  Isoproterenol ,  Clorgiline ,  Propranolol

Reference (14)：

• 1) Eisenhofer G, Kopin IJ, Goldstein DS. Catecholamine metabolism: a contemporary view with implications for physiology and medicine. Pharmacol. Rev., 56, 331-349 (2004).
• 2) Guldberg HC, Marsden CA. Catechol-O-methyl transferase: pharmacological aspects and physiological role. Pharmacol. Rev., 27, 135-206 (1975).
• 3) Langer SZ, Rubio MC. Effects of the noradrenaline metabolites on the adrenergic receptors. Naunyn Schmiedebergs Arch. Pharmacol., 276, 71-88 (1973).
• 4) Obara K, Suzuki S, Shibata H, Yoneyama N, Hamamatsu S, Yamaki F, Higai K, Tanaka Y. Noradrenaline-induced relaxation of urinary bladder smooth muscle is primarily triggered through the β₃-adrenoceptor in rats. Biol. Pharm. Bull., 42, 736-743 (2019).
• 5) Henry PJ, Goldie RG. β₁-adrenoceptors mediate smooth muscle relaxation in mouse isolated trachea. Br. J. Pharmacol., 99, 131-135 (1990).

Terms in the title (11)： 平滑筋 ,  βアドレナリン受容体 ,  弛緩 ,  カテコールアミン ,  代謝産物 ,  マウス ,  モルモット ,  気管 ,  ラット ,  大動脈 ,  評価