Art

J-GLOBAL ID：202002285956754638   Reference number：20A0536672

Structurally distinct α-synuclein fibrils induce robust parkinsonian pathology

構造的に異なるα-シヌクレイン原線維はロバストなParkinson病病理を誘導する【JST・京大機械翻訳】

Author (15)： Hayakawa Hideki (Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan) ,  Nakatani Rie (Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan) ,  Ikenaka Kensuke (Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan) ,  Aguirre Cesar (Institute of Protein Research, Osaka University, Osaka, Japan) ,  Choong Chi-Jing (Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan) ,  Tsuda Hiroshi (Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan) ,  Nagano Seiichi (Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan) ,  Koike Masato (Department of Cell Biology and Neuroscience, Juntendo University Graduate School of Medicine, Tokyo, Japan) ,  Ikeuchi Takeshi (Department of Molecular Genetics, Bioresource Science Branch, Center for Bioresources, Brain Research Institute, Niigata University, Niigata, Japan) ,  Hasegawa Masato (Department of Neuropathology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan) ,  Papa Stella M. (Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA) ,  Nagai Yoshitaka (Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan) ,  Nagai Yoshitaka (Department of Neurotherapeutics, Osaka University Graduate School of Medicine, Osaka, Japan) ,  Mochizuki Hideki (Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan) ,  Baba Kousuke (Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan)
Material： Movement Disorders
Volume： 35  Issue： 2  Page： 256-267  Publication year： 2020 
JST Material Number： W2689A  ISSN： 0885-3185  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： OBJECTIVE: Alpha-synuclein (α-...

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Thesaurus term： *pathological state ,  substantia nigra ,  aggregate ,  mutation ,  wild type ,  neurotoxicity ,  gene ,  beta-structure ,  phosphorylation ,  in vitro experiment ,  *Parkinson's disease ,  movement disorder ,  Lewy body ,  neuron ,  *robustness

Author keywords (5)： Parkinson’s disease ,  alpha-synuclein ,  Lewy body ,  propagation ,  animal model

JST classification (1)： Basic neurology  (GN01020W)

Terms in the title (5)： α-シヌクレイン ,  ロバスト ,  Parkinson病 ,  病理 ,  誘導