Art

J-GLOBAL ID：202002285965340380   Reference number：20A1826772

MicroRNA-146a Is a Wide-Reaching Neuroinflammatory Regulator and Potential Treatment Target in Neurological Diseases

マイクロRNA-146aは神経疾患における広範囲に到達する神経炎症性レギュレーターであり,潜在的な治療標的である【JST・京大機械翻訳】

Author (12)： Fan Weihao (Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China) ,  Fan Weihao (Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China) ,  Liang Chunmei (Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China) ,  Ou Mingqian (Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China) ,  Ou Mingqian (Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China) ,  Zou Ting (Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China) ,  Zou Ting (Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China) ,  Sun Furong (Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China) ,  Sun Furong (Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China) ,  Zhou Haihong (Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China) ,  Zhou Haihong (Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China) ,  Cui Lili (Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China)
Material： Frontiers in Molecular Neuroscience (Web)
Volume： 13  Page： 90  Publication year： 2020 
JST Material Number： U7082A  ISSN： 1662-5099  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Progressive functional deterio...

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Thesaurus term： neuron ,  nervous system ,  *nervous system disease ,  biomarker ,  pathogenesis ,  single nucleotide polymorphism
Semi thesaurus term： 神経変性疾患 ,  *マイクロRNA ,  標的遺伝子 ,  炎症反応 ,  *治療標的 ,  細胞型 ,  *神経系炎症 , 【Automatic Indexing@JST】

Author keywords (5)： microRNA-146a ,  neurological diseases ,  single-nucleotide polymorphisms ,  neuroinflammation ,  biomarker

JST classification (1)： Gene expression  (EC02040Q)

Reference (130)：

• Aronica E., Fluiter K., Iyer A., Zurolo E., Vreijling J., van Vliet E. A., et al. (2010). Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy. Eur. J. Neurosci. 31, 1100-1107. doi: 10.1111/j.1460-9568.2010.07122.x
• Balami J. S., Buchan A. M. (2012). Complications of intracerebral haemorrhage. Lancet Neurol. 11, 101-118. doi: 10.1016/S1474-4422(11)70264-2
• Baldeón R. L., Weigelt K., de Wit H., Ozcan B., van Oudenaren A., Sempértegui F., et al. (2014). Decreased serum level of miR-146a as sign of chronic inflammation in type 2 diabetic patients. PLoS One 9:e115209. doi: 10.1371/journal.pone.0115209
• Baluni M., Ghildiyal S., Singh D., Himanshu Reddy D., Kumar R., Dhole T. N. (2018). Increased serum microRNA-29b expression and bad recovery in Japanese encephalitis virus infected patients; A new component to improve the disease recovery. J. Neuroimmunol. 323, 56-61. doi: 10.1016/j.jneuroim.2018.07.014
• Boese A. S., Saba R., Campbell K., Majer A., Medina S., Burton L., et al. (2016). MicroRNA abundance is altered in synaptoneurosomes during prion disease. Mol. Cell. Neurosci. 71, 13-24. doi: 10.1016/j.mcn.2015.12.001

Terms in the title (4)： 神経疾患 ,  神経炎症 ,  レギュレーター ,  治療標的