Art

J-GLOBAL ID：202002286141642755   Reference number：20A0757797

Recent progress in the derivatization-based bioanalysis of disease-associated chiral metabolites

誘導体化法の進展が拓くキラル代謝物関連病態の解明

Author (4)： SUGIYAMA EIJI (静岡県大 薬) ,  MIZUNO HAJIME (静岡県大 薬) ,  TOYOOKA TOSHIMASA (静岡県大 薬) ,  TODOROKI KEN'ICHIRO (静岡県大 薬)
Material： JSBMS Letters  (JSBMS Lett)
Volume： 45  Issue： 1  Page： 4-9  Publication year： Mar. 25, 2020 
JST Material Number： L4175B  ISSN： 1881-5464  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： human(primates) ,...
Semi thesaurus term： *chiral compound ,...

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JST classification (3)： Pharmacology in general  (GW01000B) ,  Metabolism and nutrition of proteins,peptides and amino acids  (EJ02032I) ,  Diagnostics in general  (GC03001Y)

Substance index (5)： (R)-Hydroxyglutarate ,  (S)-2-Hydroxyglutaric acid ,  α-Ketoglutaric acid ,  Diacetyl-L-tartaric anhydride ,  D-Serine

Reference (36)：

• Ye D, Guan KL, Xiong Y: Metabolism, activity, and targeting of D- and L-2-hydroxyglutarates. Trends in Cancer 4: 151-165, 2018.
• Sasabe J, Miyoshi Y, Rakoff-Nahoum S, et al: Interplay between microbial D-amino acids and host D-amino acid oxidase modifies murine mucosal defence and gut microbiota. Nat Microbiol 1: 16125, 2016.
• Hesaka A, Sakai S, Hamase K, et al: D-serine feflects kidney function and diseases. Sci Rep 9: 1-8, 2019.
• Matsumoto M, Kunisawa A, Hattori T, et al: Free D-amino acids produced by commensal bacteria in the colonic lumen. Sci Rep 8: 1-7, 2018.
• Takayama T, Mizuno H, Toyo’oka T, et al: Isotope corrected chiral and achiral nontargeted metabolomics: An approach for high accuracy and precision metabolomics based on derivatization and its application to cerebrospinal fluid of patients with Alzheimer’s Disease. Anal Chem 91: 4396-4404, 2019.

Terms in the title (5)： 誘導体化 ,  進展 ,  キラル ,  代謝物 ,  病態