Art
J-GLOBAL ID：202002286573189572   Reference number：20A0789917

Discovery of PROTAC BCL-XL degraders as potent anticancer agents with low on-target platelet toxicity

低オンターゲット血小板毒性を有する強力な抗癌剤としてのProtac Bcl-X_l分解物の発見【JST・京大機械翻訳】
Author (9)：
Zhang Xuan

About Zhang Xuan

(Department of Medicinal Chemistry, College of Pharmacy, University of Florida, 1333 Center Drive, Gainesville, FL, 32610, United States)

About Department of Medicinal Chemistry, College of Pharmacy, University of Florida, 1333 Center Drive, Gainesville, FL, 32610, United States

, 
Thummuri Dinesh

About Thummuri Dinesh

(Department of Pharmacodynamics, College of Pharmacy, University of Florida, 1333 Center Drive, Gainesville, FL, 32610, United States)

About Department of Pharmacodynamics, College of Pharmacy, University of Florida, 1333 Center Drive, Gainesville, FL, 32610, United States

, 
Liu Xingui

About Liu Xingui

(Department of Pharmacodynamics, College of Pharmacy, University of Florida, 1333 Center Drive, Gainesville, FL, 32610, United States)

About Department of Pharmacodynamics, College of Pharmacy, University of Florida, 1333 Center Drive, Gainesville, FL, 32610, United States

, 
Hu Wanyi

About Hu Wanyi

(Department of Medicinal Chemistry, College of Pharmacy, University of Florida, 1333 Center Drive, Gainesville, FL, 32610, United States)

About Department of Medicinal Chemistry, College of Pharmacy, University of Florida, 1333 Center Drive, Gainesville, FL, 32610, United States

, 
Zhang Peiyi

About Zhang Peiyi

(Department of Medicinal Chemistry, College of Pharmacy, University of Florida, 1333 Center Drive, Gainesville, FL, 32610, United States)

About Department of Medicinal Chemistry, College of Pharmacy, University of Florida, 1333 Center Drive, Gainesville, FL, 32610, United States

, 
Khan Sajid

About Khan Sajid

(Department of Pharmacodynamics, College of Pharmacy, University of Florida, 1333 Center Drive, Gainesville, FL, 32610, United States)

About Department of Pharmacodynamics, College of Pharmacy, University of Florida, 1333 Center Drive, Gainesville, FL, 32610, United States

, 
Yuan Yaxia

About Yuan Yaxia

(Department of Pharmacodynamics, College of Pharmacy, University of Florida, 1333 Center Drive, Gainesville, FL, 32610, United States)

About Department of Pharmacodynamics, College of Pharmacy, University of Florida, 1333 Center Drive, Gainesville, FL, 32610, United States

, 
Zhou Daohong

About Zhou Daohong

(Department of Pharmacodynamics, College of Pharmacy, University of Florida, 1333 Center Drive, Gainesville, FL, 32610, United States)

About Department of Pharmacodynamics, College of Pharmacy, University of Florida, 1333 Center Drive, Gainesville, FL, 32610, United States

, 
Zheng Guangrong

About Zheng Guangrong

(Department of Medicinal Chemistry, College of Pharmacy, University of Florida, 1333 Center Drive, Gainesville, FL, 32610, United States)

About Department of Medicinal Chemistry, College of Pharmacy, University of Florida, 1333 Center Drive, Gainesville, FL, 32610, United States


Material：
European Journal of Medicinal Chemistry  (Eur J Med Chem)

About European Journal of Medicinal Chemistry


Volume： 192  Page： Null  Publication year： 2020 
JST Material Number： E0845A  ISSN： 0223-5234  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)
Abstract/Point：
Abstract/Point
Japanese summary of the article(about several hundred characters).
All summary is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
Anti-apoptotic protein BCL-X<s...
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Thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
enzyme

About enzyme

, 
*thrombocyte

About thrombocyte

, 
*antitumor drug

About antitumor drug

, 
tumor cell

About tumor cell

, 
human(primates)

About human(primates)

, 
ligase

About ligase

, 
degradation product

About degradation product

, 
apoptosis

About apoptosis

, 
tumorigenesis

About tumorigenesis


Semi thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
腫瘍細胞株

About 腫瘍細胞株

, 
腫瘍薬物耐性

About 腫瘍薬物耐性

, 
抗アポトーシス蛋白質

About 抗アポトーシス蛋白質

, 
癌治療

About 癌治療

, 
生存性

About 生存性

, 【Automatic Indexing@JST】
Author keywords (5)：
BCL-XL

About BCL-XL

, 
PROTAC

About PROTAC

, 
Apoptosis

About Apoptosis

, 
Platelet

About Platelet

, 
Degradation

About Degradation

JST classification (2)：
JST classification
Category name(code) classified by JST.
Enzyme in general 
(EB09010D)

About Enzyme in general

,  Fibrinolysis and blood coagulation 
(EJ03040S)

About Fibrinolysis and blood coagulation

Substance index (1)：
Substance index
Chemical Substance indexed to the Article.
ABT-263

About ABT-263

Terms in the title (6)：
Terms in the title
Keywords automatically extracted from the title.
血小板

About 血小板

, 
毒性

About 毒性

, 
抗癌剤

About 抗癌剤

, 
PROTAC

About PROTAC

, 
分解物

About 分解物

, 
発見

About 発見


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