Art

J-GLOBAL ID：202002288302666119   Reference number：20A0626557

TCR-Like CAR-T Cells Targeting MHC-Bound Minor Histocompatibility Antigens

MHC結合マイナー組織適合性抗原を標的とするTCR様CAR-T細胞【JST・京大機械翻訳】

Author (1)： Akatsuka Yoshiki (Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan)
Material： Frontiers in Immunology (Web)
Volume： 11  Page： 257  Publication year： 2020 
JST Material Number： U7074A  ISSN： 1664-3224  Document type： Article
Article type： 文献レビュー  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Minor histocompatibility antig...

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Thesaurus term： donor ,  immunogenicity ,  Chimera ,  *histocompatibility antigen ,  human leucocyte antigen ,  adoptive immunotherapy ,  affinity ,  peptide ,  T cell receptor ,  antibody ,  Heredity ,  *T cell ,  *antigen ,  targeting ,  CD3 antigen

Author keywords (5)： minor histocompatibility antigen ,  TCR-like antibody ,  adoptive immunotherapy ,  allogeneic stem cell transplantation ,  chimeric antigen receptor (CAR) cell

JST classification (2)： Immunological reaction in general  (ED03010T) ,  Infectious immunity  (ED03030P)

Reference (70)：

• Neubert D, Neubert R, Stahlmann R, Helge H. Immuno-toxicology and -pharmacology. Braz J Med Biol Res. (1989) 22:1457-73.
• Spierings E. Minor histocompatibility antigens: past, present, and future. Tissue Antigens. (2014) 84:374-60. doi: 10.1111/tan.12445
• Marijt WA, Heemskerk MH, Kloosterboer FM, Goulmy E, Kester MG, van der Hoorn MA, et al. Hematopoiesis-restricted minor histocompatibility antigens HA-1- or HA-2-specific T cells can induce complete remissions of relapsed leukemia. Proc Natl Acad Sci USA. (2003) 100:2742-7. doi: 10.1073/pnas.0530192100
• Kloosterboer FM, van Luxemburg-Heijs SA, van Soest RA, van Egmond HM, Barbui AM, Strijbosch MP, et al. Minor histocompatibility antigen-specific T cells with multiple distinct specificities can be isolated by direct cloning of IFNgamma-secreting T cells from patients with relapsed leukemia responding to donor lymphocyte infusion. Leukemia. (2005) 19:83-90. doi: 10.1038/sj.leu.2403572
• Klein CA, Wilke M, Pool J, Vermeulen C, Blokland E, Burghart E, et al. The hematopoietic system-specific minor histocompatibility antigen HA-1 shows aberrant expression in epithelial cancer cells. J Exp Med. (2002) 196:359-68. doi: 10.1084/jem.20011838

Terms in the title (6)： MHC ,  マイナー ,  組織適合性抗原 ,  標的 ,  TCR ,  T細胞