Art

J-GLOBAL ID：202002288327872484   Reference number：20A0751931

The Synthetic Curcumin Derivative CNB-001 Attenuates Thrombin-Stimulated Microglial Inflammation by Inhibiting the ERK and p38 MAPK Pathways

合成クルクミン誘導体CNB-001はERKとp38MAPK経路を阻害することによりトロンビン刺激ミクログリア炎症を減弱する

Author (3)： Akaishi Tatsuhiro (Laboratory of Pharmacology, Faculty of Pharmacy and Research Institute of Pharmaceutical Sciences, Musashino University) ,  Yamamoto Shohei (Laboratory of Pharmacology, Faculty of Pharmacy and Research Institute of Pharmaceutical Sciences, Musashino University) ,  Abe Kazuho (Laboratory of Pharmacology, Faculty of Pharmacy and Research Institute of Pharmaceutical Sciences, Musashino University)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 43  Issue： 1  Page： 138-144(J-STAGE)  Publication year： 2020 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： chemical compound ,...
Semi thesaurus term： iNOS ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=20A0751931&from=J-GLOBAL&jstjournalNo=U1402A") }}

Author keywords (10)： thrombin ,  inflammation ,  extracellular signal-regulated kinase ,  microglia ,  curcumin derivative ,  thrombin ,  inflammation ,  extracellular signal-regulated kinase ,  microglia ,  curcumin derivative

JST classification (1)： Basic research of anti-inflammatory drugs  (GW15010T)

Substance index (3)： CNB-001 ,  Sch-79797 ,  Curcumin

Reference (36)：

• 1) Liu Y, Dargusch R, Maher P, Schubert D. A broadly neuroprotective derivative of curcumin. J. Neurochem., 105, 1336-1345 (2008).
• 2) Maher P, Akaishi T, Schubert D, Abe K. A pyrazole derivative of curcumin enhances memory. Neurobiol. Aging, 31, 706-709 (2010).
• 3) Amor S, Puentes F, Baker D, Van Der Valk P. Inflammation in neurodegenerative diseases. Immunology, 129, 154-169 (2010).
• 4) Guillot-Sestier MV, Doty KR, Town T. Innate immunity fights Alzheimer’s disease. Trends Neurosci., 38, 674-681 (2015).
• 5) Mhatre SD, Tsai CA, Rubin AJ, James ML, Andreasson KI. Microglial malfunction: the third rail in the development of Alzheimer’s disease. Trends Neurosci., 38, 621-636 (2015).

Terms in the title (9)： クルクミン ,  誘導体 ,  ERK ,  阻害 ,  トロンビン ,  刺激 ,  ミクログリア ,  炎症 ,  減弱