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J-GLOBAL ID:202002291561303043   Reference number:20A2314019

計算化学を用いたRNAアプタマーの分子設計手法の確立に向けて

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Issue: 38  Page: 9-17 (WEB ONLY)  Publication year: Apr. 01, 2020 
JST Material Number: U1076A  ISSN: 2436-9152  Document type: Article
Article type: 解説  Country of issue: Japan (JPN)  Language: JAPANESE (JA)
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Research and development  ,  Nucleic acids in general 
Reference (29):
  • Tuerk, C., Gold, L., Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase, Science, 249, 505-510 (1990).
  • Ellington, A.D., Szostak, J.W., In vitro selection of RNA molecules that bind specific ligands, Nature, 346, 818-822 (1990).
  • Huang, D.B., Vu, D., Cassiday, L.A., Zimmerman, J.M., Maher III, L.J., Ghosh, G., Crystal structure of NF-κB (p50)2 complexed to a high-affinity RNA aptamer, PNAS, 100, 9268-9273 (2003).
  • Long, S.B., Long, M.B., White, R.R., Sullenger, B.A., Crystal structure of an RNA aptamer bound to thrombin, RNA, 14, 2504-2512 (2008).
  • Burgstaller, P., Famulok, M., Isolation of RNA aptamers for biological cofactors by in vitro selection, Angew. Chem. Int. Ed. Engl., 33, 1084-1087 (1994).
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