euL1db, the European database of L1-HS retrotransposon insertions in humans: euL1db

Retrotransposons, which comprises LINE, SINE and LTR-containing elements, accounts for almost half of our genome (Fig. 1). They are mobile genetics elements - also known as jumping genes - but only the L1-HS subfamily has retained the ability to jump autonomously in modern humans. Their mobilization in germline - but also some somatic tissues - contributes to human genetic diversity and to diseases, such as cancer. euL1db provides a curated and comprehensive summary of L1-HS insertion polymorphisms identified in healthy or pathological human samples and published in peer-reviewed journals. It will help understanding the link between L1 retrotransposon insertion polymorphisms and phenotype or disease.