J-GLOBAL ID:202010002452145808   Research Resource code:NBDC02156 Update date:Jul. 09, 2020

Clinical Knowledgebase: JAX-CKB

Clinical Knowledgebase: JAX-CKB
Owning Organization:
  • The Jackson Laboratory
Resource classification: Data,Database
Tag (subject)  (4): Drug ,  Genome/Gene ,  Health/Disease ,  Genetic variation
Tag (data type)  (3): 3D structure ,  Bibliography/Documents ,  Sequence
Species (1): Homo sapiens (NCBI Taxonomy ID: 9606)
The Jackson Laboratory Clinical Knowledgebase (CKB) is a semi-automated/manually curated database of gene/variant annotations, therapy knowledge, diagnostic/prognostic information, and clinical trials related to oncology. CKB not only contains current information on the protein effect of somatic gene variants, but also connects the variant to targeted therapies through an efficacy evidence annotation. In addition, CKB captures clinical trial patient eligibility criteria that include genomic alterations (genotype-specific). The public access version of CKB encompasses 82 commonly known driver genes. Users can search CKB via gene, gene variants, drug, drug class, indication, and clinical trials. The web-based version of CKB is designed to interrogate the knowledgebase for specific data attributes while also enabling a robust browse like feature when the desired content is unknown.
Source: FAIRsharing
Record maintainer: See the corresponding part in the FAIRsharing record
Record license: Creative Commons Attribution and Share-alike (CC-BY-SA) International 4.0 license

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