J-GLOBAL ID:202010015744443367   Research Resource code:NBDC02530 Update date:May. 12, 2020

CADD: Combined Annotation-Dependent Depletion

CADD: Combined Annotation-Dependent Depletion
Owning Organization:
  • University of Washington
Resource classification: Data,Database
Tag (subject)  (4): Genome/Gene ,  Genetic variation ,  Organism ,  Health/Disease
Tag (data type)  (1): Sequence
Species (1): Homo sapiens (NCBI Taxonomy ID: 9606)
It is a site for Combined Annotation-Dependent Depletion (CADD), which is a framework for scoring the deleteriousness of single nucleotide variants as well as insertion/deletions variants in the human genome. The CADD objectively weights and integrates diverse annotations by contrasting variants survived natural selection with simulated mutations. The variants those are functional, deleterious and disease causal are quantitatively sorted out its priorities across a wide range of functional categories, effect sizes and genetic architectures.
Source: NBDC
Record maintainer: Integbio Database Catalog
Record license: Creative Commons CC0 license

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