FusionGDB2: Fusion Gene annotation DataBase

• UTHealth (University of Texas Health Science Center at Houston)

FusionGDB is a database about fusion gene annotation. This database collects data of clinically relevant fusion genomes from three representative fusion gene resources: the improved database of chimeric transcripts and RNA-seq data (ChiTaRS 3.1), an integrative resource for cancer-associated transcript fusions (TumorFusions), and The Cancer Genome Atlas (TCGA). Gene assessment across pan-cancer fusion genes, open reading frame (ORF) assignment, and protein domain retention search based on multiple isoform gene structure with multiple break points were performed for the collected fusion genomes. It also provides the fusion transcript and amino acid sequences for each break point and gene isoforms. Each entry contains multiple annotation such as gene summary, assessment scores of each gene in pan-cancer, biological process gene ontologies, functional description, retention information and protein-protein interaction (PPI), related drugs and diseases through six categories.