Rchr
J-GLOBAL ID：202101000354461963
Update date: Sep. 20, 2024
Ohgita Takashi
オオギタ タカシ | Ohgita Takashi
Affiliation and department：
Job title：
Assistant professor
Research field (1)：
Pharmaceuticals - analytical and physicochemistry
Research theme for competitive and other funds (5)：
- 2024 - 2027 新規数理モデルを用いたパートナー分子によるαシヌクレイン凝集核形成制御機構の解明
- 2021 - 2024 アミロイド凝集核を構成する異常型αシヌクレインの構造特性の物理化学的解明
- 2016 - 2019 Research for bacterial type III secretion system based on needle rotation model
- 2015 - 2017 Development of pH-sensitive flagellar driven type-liposomes penetrable into tumor tissue
- 2014 - 2016 Evaluation of correlation between rotation and secretion of type III secretion apparatus for clarifying the effector secretion mechanism
Papers (33)：
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Takashi Ohgita, Koto Sakai, Nodoka Fukui, Norihiro Namba, Miyu Nakano, Yuki Kiguchi, Izumi Morita, Hiroyuki Oyama, Kouya Yamaki, Kohjiro Nagao, et al. Generation of novel anti-apoE monoclonal antibodies that selectively recognize apoE isoforms. FEBS letters. 2024. 598. 8. 902-914
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Serina Gima, Kazuya Oe, Kaneyasu Nishimura, Takashi Ohgita, Haruka Ito, Hiroyuki Kimura, Hiroyuki Saito, Kazuyuki Takata. Host-to-graft propagation of inoculated α-synuclein into transplanted human induced pluripotent stem cell-derived midbrain dopaminergic neurons. Regenerative Therapy. 2024. 25. 229-237
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Norihiro Namba, Takashi Ohgita, Hiroko Tamagaki-Asahina, Kazuchika Nishitsuji, Toshinori Shimanouchi, Takeshi Sato, Hiroyuki Saito. Amyloidogenic 60-71 deletion/ValThr insertion mutation of apolipoprotein A-I generates a new aggregation-prone segment that promotes nucleation through entropic effects. Scientific Reports. 2023. 13. 1
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Yuki Takechi-Haraya, Takashi Ohgita, Akiko Usui, Kazuchika Nishitsuji, Kenji Uchimura, Yasuhiro Abe, Ryuji Kawano, Monika I. Konaklieva, Mart Reimund, Alan T. Remaley, et al. Structural flexibility of apolipoprotein E-derived arginine-rich peptides improves their cell penetration capability. 2023
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Takashi Ohgita, Hiroki Kono, Izumi Morita, Hiroyuki Oyama, Toshinori Shimanouchi, Norihiro Kobayashi, Hiroyuki Saito. Intramolecular interaction kinetically regulates fibril formation by human and mouse α-synuclein. Scientific reports. 2023. 13. 1. 10885-10885
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MISC (9)：
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原矢佑樹, 扇田隆司, 臼井明子, 西辻和親, 西辻和親, 内村健治, 阿部康弘, 川野竜司, KONAKLIEVA Monika I, REIMUND Mart, et al. Effect of conformational constraints on apolipoprotein E-derived amphipathic peptide: insight into cell membrane penetration. 日本薬学会年会要旨集(Web). 2024. 144th
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Takashi Ohgita, Hiroki Kono, Norihiro Namba, Hiroyuki Saito. Physicochemical mechanisms of aggregation and fibril formation of α-synuclein and apolipoprotein A-I. Biophysics and physicobiology. 2024. 21. 1. e210005
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福田愛菜, 中嶋聡一, 中嶋聡一, 尾田好美, 尾田好美, 西村周泰, 西村周泰, 河嶋秀和, 木村寛之, 扇田隆司, et al. Detection of Aβ aggregates and neuroprotection by plantainoside B, an Aβ-binding compound from Bacopa monniera. 日本薬学会年会要旨集(Web). 2023. 143rd
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MIZUGUCHI-FUKASE Chiharu, OHGITA Takashi, SAITO Hiroyuki. Kinetic and Thermodynamic Analyses of Aggregation and Fibril Formation of Amyloidogenic Proteins. Seibutsu Butsuri. 2022. 62. 4. 224-227
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加藤くみ子, 八幡志穂, 原矢佑樹, 扇田隆司, 出水庸介, 斎藤博幸, 伊豆津健一. Nanoparticle tracking analysis for characterization of extracellular vesicles including exosomes. Pharm Tech Japan. 2022. 38. 2
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Books (1)：
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ベーシック薬学教科書シリーズ3 物理化学 (第2版)
化学同人 2018
Lectures and oral presentations (50)：
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ライトシート顕微鏡を用いたα-シヌクレインの脳内伝播の空間的可視化法の解析
(日本薬学会第143年会 2023)
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新規抗アポEモノクローナル抗体のアポEアイソフォーム反応特性の物理化学的評価
(日本薬学会第143年会 2023)
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ApoA-Iの構造安定性とアミロイド線維形成性に及ぼすアミロイドーシス変異の影響
(日本薬学会第143年会 2023)
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アミロイド共存タンパク質ApoA-IVの物性とアミロイド線維形成促進効果
(日本薬学会第143年会 2023)
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Bacopa monnieraに含有されるAβ結合物質plantainoside BによるAβ凝集体の検出と神経保護作用
(日本薬学会第143年会 2023)
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