Rchr
J-GLOBAL ID：202101000539532565   Update date: Oct. 14, 2025

Manabe Tadashi

マナベ タダシ | Manabe Tadashi
Affiliation and department：
University of California, San Francisco

About University of California, San Francisco


Research keywords  (4)： Developing new targeted therapies ,  MAPK signaling in lung cancer ,  Drug resistance mechanisms in lung cancer ,  Establishment of patient-derived cancer models
Research theme for competitive and other funds  (3)：
  • 2021 - 2022 Elucidation of the resistant mechanism of molecular inhibitors using lung cancer organoids
  • 2019 - 2021 Development of precision medicine for molecular inhibitor resistant patients using patient-derived cancer cell lines
  • 2017 - 2019 Identification of treatable tyrosine kinases for both lung cancer and interstitial pneumonia.
Papers (41)：
  • Trever Bivona, Tadashi Manabe, Hannah Bergo, Qingtian Li, Tim Sen Wang, Paul Severson, Nichol Miller, Catherine Lee, Elifnur Yay Donderici, Nicole Zhang, et al. Targeting BRAF Class II and III Mutations in NSCLC with the pan-RAF inhibitor Exarafenib Reveals ARAF-KSR1-Mediated Resistance and Rational Combination Strategies. 2025
  • Fumimaro Ito, Hideki Terai, Masahiro Kondo, Ryo Takemura, Ho Namkoong, Takanori Asakura, Shotaro Chubachi, Keita Masuzawa, Sohei Nakayama, Yusuke Suzuki, et al. Cluster analysis of long COVID in Japan and association of its trajectory of symptoms and quality of life. BMJ Open Respiratory Research. 2024. 11. 1. e002111-e002111
  • Deborah R. Caswell, Philippe Gui, Manasi K. Mayekar, Emily K. Law, Oriol Pich, Chris Bailey, Jesse Boumelha, D. Lucas Kerr, Collin M. Blakely, Tadashi Manabe, et al. The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance. Nature Genetics. 2024
  • Tadashi Manabe, Trever G Bivona. Remodeling of the tumor/tumor microenvironment ecosystem during KRAS G12C inhibitor clinical resistance in lung cancer. The Journal of clinical investigation. 2022. 132. 4
  • Kensuke Nakagawara, Ho Namkoong, Hideki Terai, Katsunori Masaki, Takae Tanosaki, Kyoko Shimamoto, Ho Lee, Hiromu Tanaka, Satoshi Okamori, Hiroki Kabata, et al. Comprehensive and long-term surveys of COVID-19 sequelae in Japan, an ambidirectional multicentre cohort study: study protocol. BMJ open respiratory research. 2021. 8. 1
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MISC (13)：
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Education (2)：
  • 2017 - 2020 Keio University Graduate School of Medicine Doctoral course (Medicine)
  • 2006 - 2012 Keio University School of Medicine
Professional career (2)：
  • MD (Keio University School of Medicine)
  • PhD (Keio University Graduate School of Medicine)
Work history (5)：
  • 2021/04 - 現在 University of California, San Francisco Department of Medicine, Division of Hematology/Oncology Postdoctoral Scholar-Fellow
  • 2020/04 - 2021/03 Tachikawa Hospital Department of Internal Medicine, Division of Pulmonary Medicine Medical Staff
  • 2017/04 - 2020/03 Keio University School of Medicine Department of Internal Medicine, Division of Pulmonary Medicine Assistant Professor (Fellow)
  • 2014/04 - 2018/03 Keio University School of Medicine Department of Internal Medicine Senior Resident
  • 2012/04 - 2014/03 Keio University Hospital Junior Resident
Awards (2)：
  • 2022/07 - Damon Runyon Cancer Research Foundation Fellowship Award
  • 2022/02 - International Association for the Study of Lung Cancer (IASLC) Education Award Best Fellows Oral Abstract Session
Association Membership(s) (8)：
International Association for the Study of Lung Cancer ,  American Association for Cancer Research ,  Japanese Society of Medical Oncology ,  The Japan Lung Cancer Society ,  The Japanese Respiratory Society ,  Japanese Society of Respiratory Endoscopy ,  The Japanese Society of Internal Medicine ,  Japanese Cancer Association
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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