Rchr
J-GLOBAL ID：202101001990514526   Update date: Feb. 01, 2024

ISHIGURO AKIRA

イシグロ アキラ | ISHIGURO AKIRA
Affiliation and department：
Hosei University Research Center for Micro-Nano Technology

About Hosei University Research Center for Micro-Nano Technology


Research field  (1)： Molecular biology
Research keywords  (10)： Intrinsically disordered proteins ,  Liquid-liquid phase separation (LLPS) ,  Liquid-to-solid transition (LST) ,  Amyotrophic lateral sclerosis (ALS) ,  Neurodegenerative disease ,  TDP-43 (43 kDa TAR DNA-binding protein) ,  FUS (fused in sarcoma) ,  G-quadruplex ,  Molecular interaction ,  RNA
Research theme for competitive and other funds  (9)：
  • 2023 - 2025 G-quadruplex-dependent phase transitions of ALS-associated RNA-binding proteins
  • 2022 - 2025 Study of molecular mechanisms of ALS-linked FUS protein and dysregulation.
  • 2017 - 2021 Study of interaction between TDP-43 and RNA guanine quadruplex and its disruption
  • 2013 - 2016 Comprehensive prediction of RNA-protein interactinos
  • 2013 - 2016 Anti- fibroblast growth factor 2 aptamer improves existing arthritis in murine models
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Papers (44)：
  • Yuzo Fujino, Morio Ueyama, Taro Ishiguro, Daisaku Ozawa, Hayato Ito, Toshihiko Sugiki, Asako Murata, Akira Ishiguro, Tania Gendron, Kohji Mori, et al. FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD. eLife. 2023. 12
  • Akira Ishiguro, Akira Ishihama. ALS-linked TDP-43 mutations interfere with the recruitment of RNA recognition motifs to G-quadruplex RNA. Scientific reports. 2023. 13. 1. 5982-5982
  • Hiraku Takada, Kaede Kijima, Akira Ishiguro, Akira Ishihama, Tomohiro Shimada. Genomic SELEX Reveals Pervasive Role of the Flagella Master Regulator FlhDC in Carbon Metabolism. International journal of molecular sciences. 2023. 24. 4
  • Akira Ishiguro, Akira Ishihama. Essential Roles and Risks of G-Quadruplex Regulation: Recognition Targets of ALS-Linked TDP-43 and FUS. Frontiers in molecular biosciences. 2022. 9. 957502-957502
  • Akira Ishiguro, Jun Lu, Daisaku Ozawa, Yoshitaka Nagai, Akira Ishihama. ALS-linked FUS mutations dysregulate G-quadruplex-dependent liquid-liquid phase separation and liquid-to-solid transition. Journal of Biological Chemistry. 2021. 297. 5. 101284-101284
ｍore...
MISC (5)：
  • 野間崇志, 山本遼介, 下理恵子, 木村展之, 石黒亮, 昆隆英. mRNAグアニン四重鎖との分子間相互作用に影響するTDP-43ALS変異の同定. 日本分子生物学会年会プログラム・要旨集(Web). 2016. 39th
  • ISHIGURO A., SANO T. Quantification of Viroid RNA in Host Plant with Microplate Hybridization. Annals of the Phytopathological Society of Japan. 1995. 61. 6. 639-639
  • ISHIGURO A., SANO T. Recombination of the Terminal Right Domain of CEVd and HSVd; the Effect on the Replication, Pathogenicity and Host Specificity. Annals of the Phytopathological Society of Japan. 1995. 61. 3. 279-280
  • ISHIGURO A, SANO T, OWENS R.A. Recombination of the Terminal Right Domain of CEVd and HSVd : the Effect on the Replication and Pathogenicity. Annals of the Phytopathological Society of Japan. 1994. 60. 6. 764-764
  • SANO T., ISHIGURO A. A Chimeric Citrus Exocortis Viroid Containing the Terminal Right Domain of Hop Stunt Viroid is Viable. Annals of the Phytopathological Society of Japan. 1993. 59. 6. 765-765
Books (2)：
  • 新機能抗体開発ハンドブック
    双文社 2012
  • 改訂第3版 分子生物学イラストレイテッド
    羊土社 2009
Education (4)：
  • 1996 - 1999 The Graduate University for Advanced Studies School of Life Science Department of Genetics
  • 1994 - 1996 Hirosaki University
  • 1990 - 1994 Hirosaki University
  • 1987 - 1990 札幌市立札幌清田高校 普通科
Work history (4)：
  • 2014/04 - 現在 Hosei University Research Center for Micro-Nano Technology
  • 2008/04 - 2014/03 東京大学医科学研究所 基礎医科学部門 特任研究員;特任助教;助教;特任准教授
  • 2002/11 - 2008/03 独立行政法人理化学研究所 脳科学総合研究センター 研究員
  • 1999/10 - 2002/10 The University of California, San Diego Center for Molecular Genetics Post doctor
Association Membership(s) (3)：
日本神経化学会 ,  日本生化学会 ,  日本分子生物学会
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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