Rchr
J-GLOBAL ID：202101004185792365
Update date: Feb. 01, 2024
Iezaki Takashi
イエザキ タカシ | Iezaki Takashi
Affiliation and department：
Research field (2)：
Pharmacology
, Pharmacology
Research theme for competitive and other funds (5)：
- 2021 - 2024 自己増幅型RNAとナノ脂質粒子DDSを用いた軟骨無形性症治療法開発研究
- 2018 - 2019 Smurf2によるグリオーマ幹細胞制御機構
- 2016 - 2019 mTORC1 in osteoblastic niche regulates progression of acute myeloid leukemia.
- 2016 - 2018 The MAPK Erk5 is necessary for proper skeletogenesis through a molecular axis that involves Smurfs-Smads-Sox9
- 2014 - 2016 骨芽細胞と破骨細胞の制御活性を有する新規骨粗鬆症治療薬の開発研究
Papers (48)：
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Gyujin Park, Kazuya Fukasawa, Tetsuhiro Horie, Yusuke Masuo, Yuka Inaba, Takanori Tatsuno, Takanori Yamada, Kazuya Tokumura, Sayuki Iwahashi, Takashi Iezaki, et al. L-type amino acid transporter 1 in hypothalamic neurons in mice maintains energy and bone homeostasis. JCI insight. 2023
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Sayuki Iwahashi, Jiajun Lyu, Kazuya Tokumura, Ryoma Osumi, Manami Hiraiwa, Takuya Kubo, Tetsuhiro Horie, Satoru Demura, Noriaki Kawakami, Taku Saito, et al. Conditional inactivation of the L-type amino acid transporter LAT1 in chondrocytes models idiopathic scoliosis in mice. Journal of cellular physiology. 2022. 237. 11. 4292-4302
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Takanori Yamada, Kazuya Fukasawa, Tetsuhiro Horie, Takuya Kadota, Jiajun Lyu, Kazuya Tokumura, Shinsuke Ochiai, Sayuki Iwahashi, Akane Suzuki, Gyujin Park, et al. The role of CDK8 in mesenchymal stem cells in controlling osteoclastogenesis and bone homeostasis. Stem cell reports. 2022. 17. 7. 1576-1588
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Tetsuhiro Horie, Kazuya Fukasawa, Takanori Yamada, Seiya Mizuno, Takashi Iezaki, Kazuya Tokumura, Sayuki Iwahashi, Shiho Sakai, Akane Suzuki, Takuya Kubo, et al. Erk5 in Bone Marrow Mesenchymal Stem Cells Regulates Bone Homeostasis by Preventing Osteogenesis in Adulthood. Stem cells (Dayton, Ohio). 2022. 40. 4. 411-422
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Manami Hiraiwa, Kazuya Fukasawa, Takashi Iezaki, Hemragul Sabit, Tetsuhiro Horie, Kazuya Tokumura, Sayuki Iwahashi, Misato Murata, Masaki Kobayashi, Akane Suzuki, et al. SMURF2 phosphorylation at Thr249 modifies glioma stemness and tumorigenicity by regulating TGF-β receptor stability. Communications biology. 2022. 5. 1. 22-22
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MISC (22)：
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岩橋咲幸, 門田卓也, 深澤和也, 家崎高志, 白波瀬弘明, 北尾達哉, 檜井栄一. Therapeutic inhibition of CDK8 on abnormal bone development in Achondroplasia model mice. 日本薬学会年会要旨集(Web). 2022. 142nd
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岡山靖佳, 落合信介, 堀江哲寛, 家崎高志, 深澤和也, 鎌倉昌樹, 池野久美子, 永松剛, 檜井栄一. Daily oral intake of Royal Jelly prevents cartilage degeneration in osteoarthritis model mice. 日本薬学会年会要旨集(Web). 2022. 142nd
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深澤和也, 徳村和也, 岩橋咲幸, 家崎高志, 檜井栄一. CDK8/c-MYC axis as a novel therapeutic target for glioblastoma. 日本薬学会年会要旨集(Web). 2021. 141st
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徳村和也, 岩橋咲幸, 深澤和也, 家崎高志, 檜井栄一. Skeletal development through mTOR complex-dependent and -independent pathways. 日本薬学会年会要旨集(Web). 2021. 141st
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岩橋咲幸, 徳村和也, 深澤和也, 家崎高志, 檜井栄一. Skeletal abnormalities by mTORC1 overactivation. 日本薬学会年会要旨集(Web). 2021. 141st
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Professional career (1)：
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