Rchr
J-GLOBAL ID：202101008025726035
Update date: Jun. 25, 2024
Arioka Masaki
アリオカ マサキ | Arioka Masaki
Affiliation and department：
Job title：
Lecturer/Associate professor
Research field (3)：
Tumor biology
, Surgical dentistry
, Pharmacology
Research keywords (7)：
Fibrosis
, Wnt signaling pathway
, Implant osseointegration
, Osteoporosis
, Bone biology, bone healing and bone regeneration
, Tumor microenvironment and cancer stem cells
, Developing anti-cancer drugs
Research theme for competitive and other funds (11)：
- 2024 - 2027 Development of a novel therapeutic agent to prevent the onset of heart failure associated with reperfusion therapy for acute myocardial infarction
- 2024 - 2027 Development of IPF Therapeutics Targeting Lipofibroblast Using GSK-3 Activators as Lead Compounds
- 2024 - 2027 Investigation of the potential of Differentiation-inducing factor-1 as a prophylactic agent for cancer metastasis by targeting circulating tumor cells
- 2024 - 2025 Environmental Assessment of the Impact of Hot and Humid Conditions and Energy Drinks on Workers' Circulatory Dynamics
- 2023 - 2024 Fundamental research for the development of differentiation-inducing factor-1 as a preventive agent for cancer metastasis
- 2020 - 2023 Elucidation of the mechanism of inhibition of cancer metastasis by differentiation-inducing factor-1
- 2021 - 2022 Development of Antitumor Drugs via Regulation of M2 Tumor-Associated Macrophages (TAMs) by differentiation-inducing factor-1 (DIF-1)
- 2019 - 2020 Restoration of masticatory function in osteoporotic patients by promoting alveolar bone healing using Liposomal-Wnt3a
- 2018 - 2019 Elucidation of Anti-tumor and Anti-metastatic Activity of DIF-1 in Breast Cancer
- 2017 - 2019 Evaluation of anti-tumor and anti-metastatic activities of DIF-1 on breast cancer
- 2015 - 2017 Search for bone regeneration therapy by local administration of GSK-3 inhibitors
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Papers (43)：
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Masaki Arioka, Koichi Miura, Ruzhe Han, Kazunobu Igawa, Fumi Takahashi-Yanaga, Toshiyuki Sasaguri. Mammalian target of differentiation-inducing factor-1 is mitochondrial malate dehydrogenase for activation of AMP-activated protein kinase and induction of mitochondrial fission. Life Sciences. 2024. 351. 122807-122807
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Toshihiro Noma, Shohei Yoshimoto, Yasuhiko Kamura, Masaki Arioka. Predentin's influence on clastic cell behavior in human external cervical resorption: Evidence from a case study. Journal of Dental Sciences. 2024. 19. 3. 1840-1845
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Takehiro Kishigami, Shin Ishikane, Masaki Arioka, Kazunobu Igawa, Yosuke Nishimura, Fumi Takahashi-Yanaga. 2,5-Dimethyl-celecoxib induces early termination of inflammatory responses by transient macrophage accumulation and inhibits the progression of cardiac remodeling in a mouse model of cryoinjury-induced myocardial infarction. Journal of Pharmacological Sciences. 2024. 154. 2. 97-107
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Masaki Arioka, Fumi Seto-Tetsuo, Takeru Inoue, Koichi Miura, Shin Ishikane, Kazunobu Igawa, Katsuhiko Tomooka, Fumi Takahashi-Yanaga, Toshiyuki Sasaguri. Differentiation-inducing factor-1 reduces lipopolysaccharide-induced vascular cell adhesion molecule-1 by suppressing mTORC1-S6K signaling in vascular endothelial cells. Life sciences. 2023. 335. 122278-122278
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Ishikane S, Arioka M, Takahashi-Yanaga F. Promising small molecule anti-fibrotic agents: Newly developed or repositioned drugs targeting myofibroblast transdifferentiation. Biochemical pharmacology. 2023
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Books (1)：
Lectures and oral presentations (66)：
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Celecoxib inhibited the skin fibrosis via suppression of preadipocyte- myofibroblasts transition by downregulating YAP/TAZ signaling pathway
(2023)
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The role of myofibroblasts in cardiac fibrosis: Application to the treatment of heart failure
(2023)
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2,5-ジメチルセレコキシブは一過性のマクロファージ集積による炎症反応の早期収束により冷凍焼灼心筋梗塞モデルマウスにおける心臓リモデリングの進行を抑制する
(第76回 日本薬理学会西南部会 2023)
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2,5-Dimethylcelecoxib prevents cardiac remodeling associated with myocardial ischemia/reperfusion injury in mice
(2022)
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Differentiation-inducing factor-1 inhibits cancer cell adhesion to vascular endothelial cells via curtailing VCAM-1 protein synthesis
(The 96th Annual Meeting of the Japanese Pharmacological Society 2022)
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Education (2)：
- 2010 - 2014 Kyushu University Graduate School of Dental Science
- 2002 - 2008 Kyushu University School of Dentistry
Professional career (1)：
- Ph.D. (Kyushu University)
Work history (4)：
- 2022/04 - 現在 University of Occupational and Environmental Health, Japan Department of Pharmacology, School of Medicine Lecturer/Associate Professor
- 2019/10 - 2022/03 Kyushu University Department of Clinical Pharmacology, Faculty of Medical Sciences Assistant professor
- 2017/07 - 2019/09 Stanford University Division of Plastic and Reconstructive Surgery, Department of Surgery, School of Medicine Visiting scholar
- 2014/04 - 2017/07 Kyushu University Department of Clinical Pharmacology, Faculty of Medical Sciences Assistant professor
Committee career (1)：
- 2022/04 - 現在 The Japanese Pharmacological Society Councilor
Awards (9)：
- 2019/06 - American Association Dental Research AADR Hatton Award Finalist
- 2015/11 - 48th Annual Meeting of the American Society of Nephrology Top Oral Abstracts for ASN
- 2014/06 - 日本学生支援機構 日本学生支援機構大学院第一種奨学金全額免除(特に優れた業績による返還免除)
- 2014/03 - 九州大学 九州大学 学生表彰(学術研究活動)
- 2014/03 - 九州大学大学院歯学府 藤野博賞
- 2013/10 - 日本口腔外科学会 ゴールドリボン賞
- 2013/09 - 日本口腔インプラント学会 優秀研究発表賞
- 2012/11 - 日本薬理学会 優秀発表賞
- 2012/09 - 九州大学歯学府 優秀発表賞
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Association Membership(s) (7)：
Japanese Society of Clinical Pharmacology and Therapeutics
, Japanese Association of Oral Biology
, International Association of Dental Research
, Japanese Cancer Association
, Japanese Pharmacological Society
, Japanese Society of Oral and Maxillofacial Surgery
, Japanese Society of Oral Implantology
