Rchr
J-GLOBAL ID:202101008837564640
Update date: Oct. 15, 2024
Taniguchi Keiko
タニグチ ケイコ | Taniguchi Keiko
Affiliation and department:
Job title:
Assistant professor
Research field (1):
Hygiene and public health (laboratory)
Research keywords (3):
Cancer biology
, Cancer prevention
, γ-glutamylcyclotransferase
Research theme for competitive and other funds (3):
- 2022 - 2028 Development of preemptive medicine against RB-mutated malignancies
- 2022 - 2025 Development of a novel cancer prevention methods targeting GGCT by "RB reactivation screening".
- 2020 - 2022 Development of a novel cancer prevention methods targeting GGCT by "RB reactivation screening".
Papers (15):
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Kozue Nose, Keiko Taniguchi, Mitsugu Fujita, Chiami Moyama, Masaya Mori, Mizuki Ishita, Tatsushi Yoshida, Hiromi Ii, Toshiyuki Sakai, Susumu Nakata. γ-Glutamylcyclotransferase is transcriptionally regulated by c-Jun and controls proliferation of glioblastoma stem cells through Notch1 levels. Cancer Gene Therapy. 2024
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Masaya Mori, Hiromi Ii, Mitsugu Fujita, Kozue Nose, Ayako Shimada, Risa Shiraki, Yuhi Sone, Chiami Moyama, Keiko Taniguchi, Susumu Nakata. Desert Hedgehog Down-regulation Mediates Inhibition of Proliferation by γ-Glutamylcyclotransferase Knockdown in Murine Glioblastoma Stem Cells. Cancer genomics & proteomics. 2024. 21. 5. 474-484
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Yumiko Saito, Keiko Taniguchi, Hiromi Ii, Mano Horinaka, Susumu Kageyama, Susumu Nakata, Osamu Ukimura, Toshiyuki Sakai. Identification of c-Met as a novel target of γ-glutamylcyclotransferase. Scientific reports. 2023. 13. 1. 11922-11922
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Yukie Nohara, Keiko Taniguchi, Hiromi Ii, Shun Masuda, Hiroko Kawakami, Masakatsu Matsumoto, Yasunao Hattori, Susumu Kageyama, Toshiyuki Sakai, Susumu Nakata, et al. Development of an activity-based chemiluminogenic probe for γ-glutamylcyclotransferase. Organic & biomolecular chemistry. 2023
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Hiromi Ii, Keiko Taniguchi, Taku Yoshiya, Yukie Nohara, Susumu Kageyama, Akihiro Kawauchi, Susumu Nakata. The γ-Glutamylcyclotransferase Inhibitor Pro-GA Induces an Antiproliferative Effect Through the Generation of Mitochondrial Reactive Oxygen Species. Anticancer research. 2022. 42. 9. 4311-4317
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MISC (21):
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飯居 宏美, 野瀬 梢, 茂山 千愛美, 安藤 翔太, 谷口 恵香, 吉矢 拓, 野原 由江, 影山 進, 中田 晋. γ-グルタミルトランスフェラーゼ阻害薬によるMCF7乳がん細胞の増殖抑制効果に対するミトコンドリアROS産生の寄与. 日本生化学会大会プログラム・講演要旨集. 2022. 95回. 1T16a-05
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飯居 宏美, 高木 寛子, 谷口 恵香, 茂山 千愛美, 安藤 翔太, 吉矢 拓, 野原 由江, 増田 駿, 津田 修吾, 影山 進, et al. γグルタミルシクロトランスフェラーゼ阻害剤pro-GAはMCF7担癌マウスにおいて抗腫瘍効果を示す. 日本薬学会年会要旨集. 2022. 142年会. 27PO10-09
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高木 寛子, 茂山 千愛美, 谷口 恵香, 安藤 翔太, 安藤 孝太, 松田 凌平, 遠藤 百華, 飯居 宏美, 影山 進, 中田 晋. PHB2阻害剤であるfluorizolineは乳がん細胞MCF7の細胞増殖を抑制する. 日本薬学会年会要旨集. 2021. 141年会. 28P01-252S
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谷口 恵香, 影山 進, 茂山 千愛美, 安藤 翔太, 飯居 宏美, 芦原 英司, 堀中 真野, 酒井 敏行, 河内 明宏, 中田 晋. 新規がん予防標的GGCTは、がん細胞にHIF-1 alpha発現を誘導して好気性解糖を促進する. 日本衛生学雑誌. 2021. 76. Suppl. S158-S158
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影山 進, 花田 英紀, 飯居 宏美, 吉矢 拓, 谷口 恵香, 高木 寛子, 中田 晋, 河内 明宏. Gamma-glutamylcycrotransferase阻害剤pro-GAの開発とその抗癌効果の検討. 日本泌尿器科学会総会. 2020. 108回. 860-860
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Lectures and oral presentations (40):
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c-Met発現低下を介したγ-glutamylcyclotrasnferase(GGCT)阻害による前立腺がん細胞増殖抑制の新規分子機構の解明(Identification of c-Met as a novel target of gamma-glutamylcyclotrasnferase in a prostate cancer cell line)
(日本泌尿器科学会総会 2023)
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Development of chemiluminogenic GGCT probe “LISA-103” containing BDU moiety
(日本薬学会年会要旨集(Web) 2023)
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Involvement of Desert hedgehog in the Anti-proliferative activity by GGCT knockdown in murine glioblastoma stem cells
(日本癌学会学術総会抄録集(Web) 2023)
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新規がん予防標的γ-グルタミルシクロトランスフェラーゼの阻害は,c-Met発現低下を介してがん細胞の増殖を抑制する
(がん予防学術大会プログラム・抄録集 2023)
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γ-グルタミルシクロトランスフェラーゼ活性検出用化学発光プローブLISA-103(Chemiluminecence probe LISA-103 for the detection of γ-glutamyl cyclotransferase activity)
(日本生化学会大会プログラム・講演要旨集 2022)
more...
Education (2):
- 2016 - 2020 Kyoto Pharmaceutical University
- 2010 - 2016 Kyoto Pharmaceutical University Pharmaceutical Sciences Pharmacy
Professional career (1):
- Ph.D. in pharmacy (Kyoto Pharmaceutical University)
Work history (1):
- 2020/04 - 現在 Kyoto Prefectural University of Medicine Department of Drug Discovery Medicine Assistant professor
Association Membership(s) (2):
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