Takada Yuri

タカダユリ | Takada Yuri

Affiliation and department：

Research field (2)： Bioorganic chemistry , Pharmaceuticals - chemistry and drug development

Research keywords (4)：有機合成化学 , 創薬科学 , 生物有機化学 , 有機化学

Research theme for competitive and other funds (7)：

2024 - 2027 Development of chimera molecules targeting epigenetic complexes
2022 - 2024 効率的タンパク質分解を実現する革新的分子技術の創出
2021 - 2024 Development of innovative drug candidates by target guided synthesis
2021 - 2023 大規模ライブラリー構築とAIを用いた解析によるPPI阻害ペプチド探索技術の創出
2018 - 2020 グラミシジンAの大規模構造活性相関による新規生物活性分子の創出

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Papers (17)：

Tetsuya Iida, Yukihiro Itoh, Yukari Takahashi, Yuka Miyake, Farzad Zamani, Yasunobu Yamashita, Yuri Takada, Toshiki Akiyama, Jun Ibaraki, Kyoka Okuda, et al. Identification of Proteolysis Targeting Chimeras (PROTACs) for Lysine Demethylase 5 and Their Neurite Outgrowth-Promoting Activity. Chemical and Pharmaceutical Bulletin. 2024. 72. 7. 638-647
Siyao Ni, Yuri Takada, Takaaki Ando, Shengwang Yu, Yasunobu Yamashita, Yukari Takahashi, Miho Sawada, Makoto Oba, Yukihiro Itoh, Takayoshi Suzuki. Identification of a novel histone H2A mono-ubiquitination-inhibiting cell-active small molecule. Bioorganic & medicinal chemistry letters. 2024. 105. 129759-129759
Yosuke Ota, Yukihiro Itoh, Yuri Takada, Yasunobu Yamashita, Chenliang Hu, Mano Horinaka, Yoshihiro Sowa, Mitsuharu Masuda, Toshiyuki Sakai, Takayoshi Suzuki. Design, synthesis, and biological evaluation of phenylcyclopropylamine-entinostat conjugates that selectively target cancer cells. Bioorganic & medicinal chemistry. 2024. 100. 117632-117632
Mitsuhiro Terao, Yasunobu Yamashita, Yuri Takada, Yukihiro Itoh, Takayoshi Suzuki. Structural optimization of a lysine demethylase 5 inhibitor for improvement of its cellular activity. Bioorganic & medicinal chemistry. 2024. 98. 117579-117579
Yasunobu Yamashita, Yukihiro Itoh, Yuri Takada, Takayoshi Suzuki. Epigenetic Inhibitors as Alzheimer's Disease Therapeutic Agents. Chemical & pharmaceutical bulletin. 2024. 72. 7. 630-637

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MISC (4)：

伊藤幸裕, 高田悠里, 山下泰信, 鈴木孝禎. Drug modalities for inhibition of protein-protein interactions. 実験医学. 2024. 42. 2
Yamashita Yasunobu, Takada Yuri, Itoh Yukihiro, Suzuki Takayoshi. Discovery of HDAC8-selective inhibitors and their application to PROTACs. MEDCHEM NEWS. 2023. 33. 4. 181-186
英国ケンブリッジ大学でのポスドク留学体験記. ファルマシア. 2022. 58. 2. 162-163
高田悠里. リソソーム経路を標的とする細胞外タンパク質分解誘導剤LYTAC. ファルマシア. 2021. 57. 4. 317

Professional career (1)：

Awards (2)：

Association Membership(s) (3)：

有機合成化学協会 , 日本薬学会 , 日本化学会

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