Rchr
J-GLOBAL ID：202101011631449986
Update date: Oct. 05, 2024
Hattori Masakazu
ハットリ マサカズ | Hattori Masakazu
Affiliation and department：
Research field (1)：
Immunology
Research theme for competitive and other funds (42)：
- 2024 - 2027 Drug discovery of feline chronic kidney disease by targeting feline senesce-associated T cells
- 2018 - 2020 Study on a new ajuvant that induce memory T cells efficiently
- 2017 - 2020 Control of senescence-associated T cell-induction
- 2014 - 2017 Study on the mechanism(s) of immunosenescence and its application for vaccine development.
- 2010 - 2012 Generating artificial parenchymal and hollow organs fabricated with collagen fibrils,various cells, and cytokines using a bioreactor that we have developed
- 2009 - 2012 比較ゲノム解析によるタイレリア原虫病原性進化の解明
- 2010 - 2010 人工リンパ節技術を用いた新規アジュバントの開発と高機能型抗体の作製
- 2008 - 2010 がん・病原微生物によるT細胞機能抑制の分子メカニズム解明とその制御
- 2008 - 2010 Research for a mechanism of prostate cancer metastasis through a SPA-1(Rap1GAP) signaling pathway.
- 2007 - 2007 smallGproteinを介した新たな癌転移機構の解明
- 2006 - 2007 骨髄性白血病発症モデルマウスを用いた免疫監視機構の総合的研究
- 2005 - 2007 Genome analysis of Theileria orientalis and its functional genomics
- 2005 - 2006 Study on the second immune response by using SPA-1-deficient mice.
- 2003 - 2006 Regulation and Control of Immune Surveillance
- 2005 - 2005 Raplシグナル遺伝子改変動物を用いた白血病発症に関わる免疫監視機構の総合的研究
- 2004 - 2004 慢性骨髄性白血病を発症するSPA-1遺伝子破壊マウスを用いた免疫監視機構の研究
- 2003 - 2004 A new model mice for human chronic myelogenous leukemia by the disruption of SPA-1 gene.
- 2003 - 2003 SPA-1遺伝子破壊マウスを用いた慢性骨髄性白血病発症に関わる免疫監視機構の研究
- 2000 - 2001 Regulation of T-cell and antigen-presenting cell interactions by Rapl.
- 2000 - 2001 Pattern recognition by human γδ T cells and innate immunity.
- 2000 - 2000 ヒトγδ型T細胞を用いた特異的癌免疫療法の開発
- 2000 - 2000 低分子G蛋白シグナル系を介した骨髄微小環境形成の分子機構の解析
- 1999 - 1999 造血系生成過程における低分子G蛋白シグナル系の関与
- 1998 - 1999 Essential role of transcriptional regulator Hesl in the early development of T cells.
- 1998 - 1998 低分子G蛋白シグナル系を介した造血系細胞分化制御機構
- 1998 - 1998 酸化的修飾がシグナルとなるユビキチン依存性蛋白分解の細胞機能制御における役割
- 1997 - 1998 Molecular mechanisms of lymphocyte proliferation during the development
- 1997 - 1997 酸化的修飾がシグナルとなるユビキチン依存性蛋白分解の細胞機能制御における役割
- 1995 - 1997 Development of avian component vaccine with built-in adjuvanting potencial.
- 1996 - 1996 核内GTPase活性化蛋白の機能制御に関与する細胞内蛋白質限定分解機構の解析
- 1995 - 1996 Cell cycle regulation of a lympho-hematopoietic specific Rap1GTPase-activating protein, Spa-1 in lymphocyres.
- 1995 - 1996 Molecular mechanisms for cell cycle control in the immune system
- 1995 - 1995 MHC非拘束性T細胞の抗原レセプターと認識抗原の研究
- 1995 - 1995 細胞周期調節機構における核内GTPase活性化蛋白の機能
- 1995 - 1995 Nuclear small G protein system involved in cell cycle.
- 1994 - 1994 造血組織に局在する新しいT細胞亜群の認識レパートリーの研究
- 1994 - 1994 核に局在するsmallG蛋白系による細胞増殖調節機構の解析
- 1993 - 1994 Analysis of a lympho-hematopoietic specific nuclear protein with homology to RaplGAP
- 1993 - 1994 Analysis of Ligands Involved in the T-cell Receptor Repartoire Formation of T-cells Lecalized in Hematopoiatic Tissues.
- 1993 - 1993 骨髄局在T細胞の認識レパートリー形成に関わる新しい拘束因子とその制御
- 1990 - 1991 Studies on the Signal Transduction in T Lymphocytes via Antigen and Lymphokine Receptors.
- 1989 - 1989 Large granular lymphocytesの初期分化に関する研究
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Papers (35)：
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Yuki Sato, Akiko Oguchi, Yuji Fukushima, Kyoko Masuda, Naoya Toriu, Keisuke Taniguchi, Takahisa Yoshikawa, Xiaotong Cui, Makiko Kondo, Takeshi Hosoi, et al. CD153/CD30 signaling promotes age-dependent tertiary lymphoid tissue expansion and kidney injury. The Journal of clinical investigation. 2022. 132. 2
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Mariko Nishie, Eiji Suzuki, Masakazu Hattori, Kosuke Kawaguch, Tatsuki R Kataoka, Masahiro Hirata, Fengling Pu, Takeshi Kotake, Moe Tsuda, Ayane Yamaguchi, et al. Downregulated ATP6V1B1 expression acidifies the intracellular environment of cancer cells leading to resistance to antibody-dependent cellular cytotoxicity. Cancer immunology, immunotherapy : CII. 2021. 70. 3. 817-830
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Nagahiro Minato, Masakazu Hattori, Yoko Hamazaki. Physiology and pathology of T-cell aging. International immunology. 2020. 32. 4. 223-231
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Yuji Fukushima, Nagahiro Minato, Masakazu Hattori. The impact of senescence-associated T cells on immunosenescence and age-related disorders. Inflammation and regeneration. 2018. 38. 24-24
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Koyu Ito, Akira Nakajima, Yuji Fukushima, Keiichiro Suzuki, Keiko Sakamoto, Yoko Hamazaki, Kouetsu Ogasawara, Nagahiro Minato, Masakazu Hattori. The potential role of Osteopontin in the maintenance of commensal bacteria homeostasis in the intestine. PloS one. 2017. 12. 3. e0173629
ｍore...
MISC (3)：
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Mariko Nishie, Eiji Suzuki, Kosuke Kawaguchi, Keiko Sakamoto, Yuji Fukushima, Masakazu Hattori, Tomoharu Sugie, Masakazu Toi. Downregulation of ATP6V1B1 in HER2-overexpressing human breast cancer cell line leads resistance against trastuzumab-mediated antibody-dependent cellular cytotoxicity. CANCER RESEARCH. 2015. 75
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Kaoru Murata, Masakazu Hattori, Yoko Hamazaki, Kyoko Masuda, Nagahiro Minato. A mechanism for the control of cell cycle progression by a bHLH transcriptional factor Hes1. CELL STRUCTURE AND FUNCTION. 2004. 29. 79-79
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原 暁, 山崎 晶, 中世古 知昭, 服部 雅一, 湊 長博, 斉藤 隆. CTLA-4によるネガティブシグナル伝達におけるRap-1の関与. 日本免疫学会総会・学術集会記録. 2000. 30. 186-186
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