Okamura Tomohisa

オカムラトモヒサ | Okamura Tomohisa

Affiliation and department：
Job title： Associate Professor

Research field (1)： Allergies and connective tissue disease

Research theme for competitive and other funds (9)：

2022 - 2025 マルチオームシングルセル解析を用いた自己免疫疾患における加齢関連T細胞の機能解析
2021 - 2024 Mechanisms of pathogenic B cell differentiation associated with genetic risk for systemic lupus erythematosus.
2019 - 2022 エピゲノム解析による自己免疫性間質性肺炎発症機構の解明と新規バイオマーカーの探索
2016 - 2019 Cytokine synergy-mediated control of humoral immune tolerance
2013 - 2016 Regulation of autoantibody production by regulatory T cells expressing anergy-associated genes

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Papers (196)：

Shinji Izuka, Toshihiko Komai, Takahiro Itamiya, Mineto Ota, Saeko Yamada, Yasuo Nagafuchi, Hirofumi Shoda, Kosuke Matsuki, Kazuhiko Yamamoto, Tomohisa Okamura, et al. Integration of transcriptome and immunophenotyping data highlights differences in the pathogenetic kinetics of B cells across immune-mediated disease. RMD open. 2025. 11. 2
諏訪雄一, 山田紗依子, 牛島俊征, 高橋秀侑, 岡村僚久, 永渕泰雄, 藤尾圭志. 関節リウマチにおける末梢血及び関節局所樹状細胞のシングルセル動態解析. 日本臨床免疫学会総会プログラム・抄録集. 2024. 52回. 81-81
Haruka Tsuchiya, Mineto Ota, Haruka Takahashi, Hiroaki Hatano, Megumi Ogawa, Sotaro Nakajima, Risa Yoshihara, Tomohisa Okamura, Shuji Sumitomo, Keishi Fujio. Epigenetic targets of Janus kinase inhibitors are linked to genetic risks of rheumatoid arthritis. Inflammation and regeneration. 2024. 44. 1. 29-29
Ayaka Iwata, Juri Maruyama, Shibata Natsuki, Akira Nishiyama, Tomohiko Tamura, Minoru Tanaka, Shigeyuki Shichino, Takao Seki, Toshihiko Komai, Tomohisa Okamura, et al. Egr2 drives the differentiation of Ly6Chi monocytes into fibrosis-promoting macrophages in metabolic dysfunction-associated steatohepatitis in mice. Communications biology. 2024. 7. 1. 681-681
Shinji Izuka, Toshihiko Komai, Takahiro Itamiya, Mineto Ota, Yasuo Nagafuchi, Hirofumi Shoda, Kosuke Matsuki, Kazuhiko Yamamoto, Tomohisa Okamura, Keishi Fujio. Machine learning-driven immunophenotypic stratification of mixed connective tissue disease corroborating the clinical heterogeneity. Rheumatology (Oxford, England). 2024

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MISC (39)：

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Patents (2)：

B細胞活性化の抑制剤及び自己免疫疾患の治療剤
新規T細胞

Books (15)：

Cytotoxic CD4+ T cells in connective tissue diseases.
HOKURYUKAN 2023
IL-10ファミリーによる免疫制御機構
医歯薬出版株式会社 2019
LAG3陽性制御性T細胞による免疫制御機構
医歯薬出版株式会社 2019
マルチオミックス解析に基づく自己免疫疾患の個別化医療
北隆館 2019
Qa-1拘束性CD8陽性制御性T細胞の分化と機能
医歯薬出版株式会社 2018

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Association Membership(s) (4)：

日本内科学会 , 日本リウマチ学会 , 日本免疫学会 , 日本臨床免疫学会

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