Okamura Tomohisa

オカムラトモヒサ | Okamura Tomohisa

Affiliation and department：
Job title： Associate Professor

Research field (1)： Allergies and connective tissue disease

Research theme for competitive and other funds (9)：

2022 - 2025 マルチオームシングルセル解析を用いた自己免疫疾患における加齢関連T細胞の機能解析
2021 - 2024 Mechanisms of pathogenic B cell differentiation associated with genetic risk for systemic lupus erythematosus.
2019 - 2022 エピゲノム解析による自己免疫性間質性肺炎発症機構の解明と新規バイオマーカーの探索
2016 - 2019 Cytokine synergy-mediated control of humoral immune tolerance
2013 - 2016 Regulation of autoantibody production by regulatory T cells expressing anergy-associated genes

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Papers (109)：

Haruka Tsuchiya, Mineto Ota, Haruka Takahashi, Hiroaki Hatano, Megumi Ogawa, Sotaro Nakajima, Risa Yoshihara, Tomohisa Okamura, Shuji Sumitomo, Keishi Fujio. Epigenetic targets of Janus kinase inhibitors are linked to genetic risks of rheumatoid arthritis. Inflammation and regeneration. 2024. 44. 1. 29-29
Ayaka Iwata, Juri Maruyama, Shibata Natsuki, Akira Nishiyama, Tomohiko Tamura, Minoru Tanaka, Shigeyuki Shichino, Takao Seki, Toshihiko Komai, Tomohisa Okamura, et al. Egr2 drives the differentiation of Ly6Chi monocytes into fibrosis-promoting macrophages in metabolic dysfunction-associated steatohepatitis in mice. Communications biology. 2024. 7. 1. 681-681
Shinji Izuka, Toshihiko Komai, Takahiro Itamiya, Mineto Ota, Yasuo Nagafuchi, Hirofumi Shoda, Kosuke Matsuki, Kazuhiko Yamamoto, Tomohisa Okamura, Keishi Fujio. Machine learning-driven immunophenotypic stratification of mixed connective tissue disease corroborating the clinical heterogeneity. Rheumatology (Oxford, England). 2024
Kazuki M Matsuda, Hirohito Kotani, Kei Yamaguchi, Chihiro Ono, Taishi Okumura, Koji Ogawa, Ayako Miya, Ayaka Sato, Rikako Uchino, Murakami Yumi, et al. Autoantibodies to nuclear valosin-containing protein-like protein: systemic sclerosis-specific antibodies revealed by in vitro human proteome. Rheumatology (Oxford, England). 2024
Mineto Ota, Masahiro Nakano, Yasuo Nagafuchi, Satomi Kobayashi, Hiroaki Hatano, Ryochi Yoshida, Yuko Akutsu, Takahiro Itamiya, Nobuhiro Ban, Yumi Tsuchida, et al. Multimodal repertoire analysis unveils B cell biology in immune-mediated diseases. Annals of the Rheumatic Diseases. 2023. ard-2023

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MISC (39)：

Matsuda Kazuki M., Kotani Hirohito, Yamaguchi Kei, Okumura Taishi, Fukuda Eriko, Kono Masanori, Hisamoto Teruyoshi, Kawanabe Ruriko, Norimatsu Yuta, Kuzumi Ai, et al. Impact of anti-transcobalamin receptor antibodies on cutaneous arteritis(タイトル和訳中). 日本研究皮膚科学会年次学術大会・総会プログラム. 2022. 47回. 187-187
西脇彩, 駒井俊彦, 永渕泰雄, 永渕泰雄, 太田峰人, 太田峰人, 吉田良知, 波多野裕明, 大久保麻衣, 小林聖美, et al. IgG4関連疾患における末梢血免疫担当細胞サブセットとBCRレパトア解析. 日本臨床免疫学会総会プログラム・抄録集. 2021. 49th
YAMADA Saeko, NAGAFUCHI Yasuo, OTA Mineto, TAKESHIMA Yusuke, HATANO Hiroaki, IWASAKI Yukiko, SUMITOMO Shuji, OKAMURA Tomohisa, SHODA Hirofumi, YAMAMOTO Kazuhiko, et al. Immune cell profiling of rheumatoid arthritis identified plasmablast pathways as key correlates with treatment resistance. 日本リウマチ学会総会・学術集会プログラム・抄録集. 2020. 64th (CD-ROM)
駒井俊彦, 岡村僚久, 井上眞璃子, 岩崎由希子, 住友秀次, 庄田宏文, 山本一彦, 藤尾圭志. 自己免疫性疾患と病態抑制性サイトカイン協調によるB細胞の免疫代謝制御機構. アレルギー. 2019. 68. 4-5. 521-521
Mariko Inoue, Tomohisa Okamura, Toshihiko Komai, Kazuhiko Yamamoto, Keishi Fujio. CD4+CD25-LAG3+ regulatory T cells in humoral immunity. Clinical and Experimental Neuroimmunology. 2019. 10. 1. 4-11

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Patents (2)：

B細胞活性化の抑制剤及び自己免疫疾患の治療剤
新規T細胞

Books (15)：

Cytotoxic CD4+ T cells in connective tissue diseases.
HOKURYUKAN 2023
IL-10ファミリーによる免疫制御機構
医歯薬出版株式会社 2019
LAG3陽性制御性T細胞による免疫制御機構
医歯薬出版株式会社 2019
マルチオミックス解析に基づく自己免疫疾患の個別化医療
北隆館 2019
Qa-1拘束性CD8陽性制御性T細胞の分化と機能
医歯薬出版株式会社 2018

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Association Membership(s) (4)：

日本内科学会 , 日本リウマチ学会 , 日本免疫学会 , 日本臨床免疫学会

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