ISHIMA TAMAKI

イシマタマキ | ISHIMA TAMAKI

Affiliation and department：

Research keywords (4)：タクロリムス誘導性腎毒性多剤併用(Polypharmacy) 抗精神病薬(フェノチアジン系) 抗うつ薬の分子機構アポモルフィン誘導体クロザピン治療抵抗性 , Nrf2活性化 NAD+/NADH代謝還元ストレス(Reductive Stress) ミトコンドリア病 Leigh症候群フェロトーシス阻害メタボローム解析コエンザイムQ10酸化還元状態 LC-MS/MS定量法 , bipolar disorder abnormality ミトコンドリア異常 postmortem brain 双極性障害脂肪酸のβ酸化 Patients Metabolomics mitochondria 統合失調症 , 精神薬理学 / 神経突起伸長 / アリピプラゾール / カルシウムシグナリング / 熱ストレスタンパク質 / IP3受容体 / 双極性障害 / iPS / 肝細胞

Research theme for competitive and other funds (6)：

2022 - 2025 マルチオミックス解析を駆使した家族性大動脈瘤・解離の素因解明
2021 - 2024 Study of molecular mechanisms underlying antidepressant actions of (R)-ketamine
2018 - 2020 Study on the etiology of bipolar disorder using iPS cells
2015 - 2017 Metabolomics analysis of CSF from bipolar disorder patients
2012 - 2017 Microendophenotype of psychiatric disorders by glutamatergic signal

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Papers (92)：

Sho Nishida, Tamaki Ishima, Daiki Iwami, Ryozo Nagai, Kenichi Aizawa. Trans-Omic Analysis Identifies the ‘PRMT1-STAT3-Integrin αVβ6 Axis’ as a Novel Therapeutic Target in Tacrolimus-Induced Chronic Nephrotoxicity. International Journal of Molecular Sciences. 2025
Shota Tomida, Hironori Okuhata, Tamaki Ishima, Ryozo Nagai, Kenichi Aizawa. Loss of Myh11 K1256 Dysregulates the Extracellular Matrix and Focal Adhesion by Inhibiting Zyxin-Activated Transcription. International Journal of Molecular Sciences. 2025
Sho Nishida, Tamaki Ishima, Daiki Iwami, Ryozo Nagai, Kenichi Aizawa. DHA-Triacylglycerol Accumulation in Tacrolimus-Induced Nephrotoxicity Identified by Lipidomic Profiling. International Journal of Molecular Sciences. 2025
Tamaki Ishima, Hitoshi Osaka, Ryozo Nagai, Kenichi Aizawa. A Highly Potent Apomorphine Derivative Enhancing Neurite Outgrowth via Nrf2 Activation. Antioxidants. 2025
Sho Nishida, Tamaki Ishima, Daiki Iwami, Ryozo Nagai, Kenichi Aizawa. Whole Blood Metabolomic Profiling of Mice with Tacrolimus-Induced Chronic Nephrotoxicity: NAD+ Depletion with Salvage Pathway Impairment. Antioxidants (Basel, Switzerland). 2025. 14. 1

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MISC (7)：

佐々木剛, 佐々木剛, 橋本謙二, 小田靖典, 石間環, 焼田まどか, 倉田勉, 久能勝, 久能勝, 高橋純平, et al. 児童・思春期治療抵抗性うつ病と血清オキシトシン. 日本臨床精神神経薬理学会プログラム・抄録集. 2017. 27th
山森英長, 橋本亮太, 石間環, 岸フク子, 安田由華, 大井一高, 藤本美智子, 伊藤彰, 橋本謙二, 武田雅俊. クロザピン治療を受けた治療抵抗性統合失調症患者血漿中のmature BDNFとMMP-9の濃度の検討(Plasma levels of mature brain-derived neurotrophic factor(BDNF) and matrix metalloproteinase-9(MMP-9) in treatment-resistant schizophrenia treated with clozapine). 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集. 2013. 23回・43回. 232-232
HASHIMOTO Kenji, ISHIMA Tamaki, FUJITA Yuko, ZHANG Lin. Antibiotic drug minocycline : a potential therapeutic drug for methamphetamine-related disorders. 2013. 48. 2. 118-125
T. Ishima, M. Iyo, K. Hashimoto. Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by aripiprazole. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012. 15. 162-162
Y. Fujita, H. Chen, J. Wu, J. Zhang, T. Ishima, M. Iyo, K. Hashimoto. Sulforaphane as a therapeutic drug for methamphetamine abuse. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012. 15. 70-70

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Professional career (1)：

博士(医学) (千葉大学)

Work history (4)：

2025/04 - 現在 Jichi Medical University Hospital Division of Translational Research Clinical Research Center
2021/12 - 2025/03 Jichi Medical University Division of Clinical Pharmacology, Department of Pharmacology
2007/02 - 2021/09 Chiba University Division of Clinical Neuroscience, Center for Forensic Mental Health Project Assistant Professor
2005/05 - 2007/01 Chiba University

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