Rchr
J-GLOBAL ID：202101015036153726
Update date: Oct. 07, 2025
Hishiki Tomoro
ヒシキ トモロウ | Hishiki Tomoro
Affiliation and department：
Job title：
Professor
Research theme for competitive and other funds (20)：
- 2025 - 2028 高機能リポソームを用いた小児肝がんに対する新規光免疫治療法の開発
- 2023 - 2026 神経芽腫に対する抗GD2抗体及びiPS細胞由来NKT細胞を用いた免疫療法の開発
- 2023 - 2026 Comprehensive epigenetic analysis of the umbilical cord in patients with congenital diaphragmatic hernia
- 2022 - 2025 Molecular mechanism of biliary tract carcinomas arising from patients with pancreaticobiliary malfunction
- 2021 - 2024 インドシアニングリーン修飾リポソームを用いた小児肝がん新規治療法の確立
- 2021 - 2024 神経芽腫難治微小病変の可視化とセラノスティクスによる新規治療開発
- 2017 - 2021 Development for a new histobiological risk stratification and establishing of genomic medicine for pediatric malignant solid tumors
- 2016 - 2020 Study of clinical states and infrastructure development of International co-operative clinical trial for childhood liver tumors by children's cancer study group
- 2014 - 2017 Unveiling the mechanism of recurrence and chemoresistance in neuroblastoma using genomewide and epigenomewide analysis
- 2013 - 2016 Development of non-invasive diagnosis and novel therapies for pediatric solid tumor
- 2011 - 2015 Survey of childhood liver tumors in Asian area and infrastructural development of international collaboration study by Japanese study group for pediatric liver tumors (JPLT)
- 2011 - 2013 Development of a novel therapeutic approach for pediatric malignant solid tumors using NKT cell-mediated immune system
- 2010 - 2012 Establishment of a novel therapeutic approach targeting cancer stem cells of neuroblastoma using onclytic virus
- 2010 - 2012 Molecular analysis for developing the newtargeting therapy in Japanese Pediatric Liver Tumor study group
- 2009 - 2011 Cytokine profile in biliary atresia patients
- 2008 - 2010 Establishment of a novel therapeutic approach for neuroblastoma using replication-compitent HSV-1 virus vector
- 2008 - 2010 Surveillance of current incidence and infrastructure development of international collaboration for childhood liver cancers by Japanese study group for pediatric liver tumor
- 2007 - 2009 molecular analyses and translational research of neuroblastoma based upon a clinical trial of the nation-wide group study
- 2006 - 2008 Immune system of the intestinal mucosa and effects of probiotics in inflammatorybowel disease
- 2005 - 2007 神経芽腫の分化・増殖・生存におけるsrcチロシンキナーゼの役割に関する研究
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Papers (475)：
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Lea Amelie Jung, Salih Demir, Alina Hotes, Eiso Hiyama, Tomoro Hishiki, Emilie Indersie, Sophie Branchereau, Stefano Cairo, Roland Kappler. Targeting HSP90 with Ganetespib to Induce CDK1 Degradation and Promote Cell Death in Hepatoblastoma. Cancers. 2025
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Katsuhiro Nishimura, Takahiro Aoki, Midori Kobayashi, Mariko Takami, Ko Ozaki, Keita Ogawa, Wang Hongxuan, Daiki Shimizu, Daisuke Katsumi, Hiroko Yoshizawa, et al. Antibody-Dependent Cellular Cytotoxicity of iPS Cell-Derived Natural Killer T Cells by Anti-GD2 mAb for Neuroblastoma. Cancer science. 2025
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Salih Demir, Alina Hotes, Tanja Schmid, Stefano Cairo, Emilie Indersie, Claudio Pisano, Eiso Hiyama, Tomoro Hishiki, Christian Vokuhl, Sophie Branchereau, et al. Drug prioritization identifies panobinostat as a tailored treatment element for patients with metastatic hepatoblastoma. Journal of experimental & clinical cancer research : CR. 2024. 43. 1. 299-299
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Eiso Hiyama, Tomoro Hishiki, Kenichi Yoshimura, Mark Krailo, Rudolf Maibach, Beate Haeberle, Arun Rangaswami, Dolores Lopez-Terrada, Marcio H Malogolowkin, Marc Ansari, et al. Upfront or delayed surgery in resectable hepatoblastoma: analysis from the children's hepatic tumors international collaboration database. EClinicalMedicine. 2024. 76. 102811-102811
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Isamu Saeki, Kohmei Ida, Sho Kurihara, Kenichiro Watanabe, Makiko Mori, Tomoro Hishiki, Akiko Yokoi, Junya Fujimura, Shohei Honda, Yuki Nogami, et al. Successful treatment of young childhood standard-risk hepatoblastoma with cisplatin monotherapy using a central review system. Pediatric blood & cancer. 2024. e31255
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MISC (94)：
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今田 寛, 高谷 具純, 吉川 聡子, 菱木 知郎, 市川 智彦, 生水 真紀夫, 濱田 洋通. アンドロゲン不応症の1例. 日本小児科学会雑誌. 2022. 126. 11. 1535-1536
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大平 美紀, 中村 洋子, 瀧本 哲也, 中澤 温子, 菱木 知郎, 松本 公一, 七野 浩之, 家原 知子, 永瀬 浩喜, 福島 敬, et al. 本邦で診断された神経芽腫605例の国際リスク分類マーカーの後方視的解析(Retrospective analysis of INRG clinical and genomic factors for 605 neuroblastomas in Japan). 日本癌学会総会記事. 2022. 81回. J-1067
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服部 真也, 横田 元, 向井 宏樹, 日野 もえ子, 中田 光政, 菱木 知郎, 宇野 隆. 肝芽腫患者に頻発する骨折の検討. 日本小児放射線学会雑誌. 2021. 37. Suppl. 88-89
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米田 光宏, 家原 知子, 菱木 知郎, 横田 勲, 高橋 秀人, 手良向 聡, 上條 岳彦, 中澤 温子, 瀧本 哲也, 柳生 茂希, et al. 神経芽腫低リスクプロトコール(JN-L-10)におけるIDRFの検討. 日本小児外科学会雑誌. 2021. 57. 2. 301-301
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米田 光宏, 家原 知子, 菱木 知郎, 横田 勲, 高橋 秀人, 手良向 聡, 上條 岳彦, 中澤 温子, 瀧本 哲也, 柳生 茂希, et al. 神経芽腫低リスクプロトコール(JN-L-10)におけるIDRFの検討. 日本小児外科学会雑誌. 2021. 57. 2. 301-301
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Lectures and oral presentations (4)：
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P40-03 当科における小児急性虫垂炎の治療方針 : 重症度に応じた手術法の選択による総合的なトレーニングを目指して(ポスターセッション40 手術の教育)
(日本小児外科学会雑誌 2012)
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P39-05 子育てしながら小児外科医として働き続けるためには何が必要か(ポスターセッション39 女性外科医の望みと悩み)
(日本小児外科学会雑誌 2012)
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PD1-20 当科で経験した小児固形異物誤飲症例の検討(ポスター展示1)
(日本小児外科学会雑誌 2012)
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PD1-02 当科におけるリンパ管腫症例の検討と難治症例に対するアプローチ(ポスター展示1)
(日本小児外科学会雑誌 2012)
Education (1)：
- 1996 - 2000 Chiba University Graduate School of Medicine
Work history (12)：
- 2020/01 - 現在 Chiba University Graduate School of Medicine Professor of Pediatric Surgery
- 2016/07 - 2019/12 National Cancer Center Pediatric Surgical Oncology Chief
- 2016/07 - 2019/12 National Center for Child Health and Development Children's Cancer Center Chief
- 2013/04 - 2016/07 Chiba Children's Hospital Faculty
- 2006/10 - 2013/03 Chiba University School of Medicine Associate professor
- 2005/04 - 2006/09 Chiba University School of Medicine Assistant professor
- 2004/04 - 2005/03 Chiba University Hospital Surgical fellow
- 2003/04 - 2004/03 Kimitsu Chuo Hospital
- 2002/04 - 2003/03 Chiba University Hospital Surgical fellow
- 2000/04 - 2002/03 Children's Hospital of Philadelphia Division of Oncology Research Associate
- 1994/10 - 1996/03 Chiba Children's Hospital resident
- 1993/04 - 1994/10 Chiba University Hospital Resident
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