Rchr
J-GLOBAL ID：202101015996167233
Update date: Sep. 17, 2024
Kubota Hiroyuki
クボタ ヒロユキ | Kubota Hiroyuki
Affiliation and department：
Job title：
Section Head
Research field (6)：
Pathobiochemistry
, Medical biochemistry
, Metabolism and endocrinology
, Molecular biology
, Applied molecular and cellular biology
, Cell biology
Research keywords (3)：
Diabetic kidney disease
, Diabetes mellitus
, Proteome
Research theme for competitive and other funds (16)：
- 2021 - 2024 The role of PDK1-FoxO signaling pathway in the development of podocyte injury
- 2019 - 2022 Development of Diagnostic Methods for detecting Diabetic Nephropathy
- 2014 - 2017 The role of insulin signaling pathway on the development of diabetic nephropathy
- 2013 - 2016 Proteomic Analysis of Serum Biomarkers for Pre-diabetes
- 2014 - 2015 糖尿病腎症に関連する新規尿蛋白質に基づいた診断法の開発
- 2011 - 2013 The role of lipoprotein receptor LR11 in diabetic complications
- 2008 - 2009 Roles of wingless-related MMTV integration site 5B in type 2 diabetes mellitus
- 2007 - 2008 Amelioration of pathological phenotypes of vascular smooth muscle cells by the sLR11 regulation
- 2007 - 2008 Mechanism of angiogenesis for adipocytes for the application to the stable transplantation technique
- 2006 - 2007 脂肪細胞の機能修飾とインスリン抵抗性発症における脂肪合成関連遺伝子の役割
- 2005 - 2006 Molecular analysis and clinical application of LR11 in SMCs.
- 2004 - 2005 Molecular mechanism of cross-talk between adipocytes and vascular cells.
- 2004 - 2005 後期糖化反応生成物による脂肪細胞の機能修飾と動脈硬化発生における役割の解明
- 2002 - 2003 MMP-12トランスジェニックウサギを用いた動脈硬化発生機序の解析
- 2000 - 2001 マトリックスメタロプロテアーゼを過剰発現するトランスジェニックウサギモデルの開発:動脈硬化病変(プラーク)の安定化に及ぼすMMP-12の影響について
- 1999 - 2001 FUNCTIONAL ROLE OF LIPOPROTEIN LIPASE IN ATHEROGENESIS - A STUDY ON TRANSGENIC RABBITS EXPRESSING HUMAN LIPOPROTEIN LIPASE
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Papers (47)：
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Toshiya Matsukawa, Takashi Yagi, Tohru Uchida, Mashito Sakai, Masaru Mitsushima, Takao Naganuma, Hiroyuki Yano, Yuka Inaba, Hiroshi Inoue, Keisuke Yanagida, et al. Hepatic FASN deficiency differentially affects nonalcoholic fatty liver disease and diabetes in mouse obesity models. JCI insight. 2023. 8. 17
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Daishi Hirano, Hiroyuki Unoki-Kubota, Toshiyuki Imasawa, Ritsuko Yamamoto-Honda, Hiroshi Kajio, Shigeo Yamashita, Yuka Fukazawa, Naoto Seki, Mitsuhiko Noda, Yasushi Kaburagi. Independent risk factors of rapid glomerular filtration rate decline in patients with type 2 diabetes with preserved kidney function and normoalbuminuria: A multicenter cohort study. Journal of diabetes investigation. 2023. 14. 7. 874-882
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Masahiro Ishikane, Hiroyuki Unoki-Kubota, Ataru Moriya, Satoshi Kutsuna, Honami Ando, Yasushi Kaburagi, Tetsuya Suzuki, Noriko Iwamoto, Moto Kimura, Norio Ohmagari. Evaluation of the QIAstat-Dx Respiratory SARS-CoV-2 panel, a rapid multiplex PCR method for the diagnosis of COVID-19. Journal of Infection and Chemotherapy. 2022. 28. 6. 729-734
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Wakiko Iwata, Hiroyuki Unoki-Kubota, Hideki Kato, Akira Shimizu, Michihiro Matsumoto, Toshiyuki Imasawa, Arisa Igarashi, Kenji Matsumoto, Tetsuo Noda, Yasuo Terauchi, et al. Podocyte-specific deletion of tubular sclerosis complex 2 promotes focal segmental glomerulosclerosis and progressive renal failure. PloS one. 2020. 15. 3. e0229397
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Hiroyuki Yano, Mashito Sakai, Toshiya Matsukawa, Takashi Yagi, Takao Naganuma, Masaru Mitsushima, Satoshi Iida, Yuka Inaba, Hiroshi Inoue, Hiroyuki Unoki-Kubota, et al. PHD3 regulates glucose metabolism by suppressing stress-induced signalling and optimising gluconeogenesis and insulin signalling in hepatocytes. Scientific Reports. 2018. 8. 1. 14290-14290
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MISC (22)：
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久保田浩之, 今澤俊之. An integrated multi-omics approaches to elucidate the pathogenesis of chronic kidney disease. 腎と透析. 2021. 91. 5. 873-876
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久保田浩之, 今澤俊之. Genetics of diabetic kidney disease. 腎と透析. 2021. 91. 4. 519-523
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今澤 俊之, 久保田 浩之, 平野 大志, 北村 博司, 鏑木 康志. 腎臓研究の最前線 多層的オミックス解析によるCKD研究. 日本腎臓学会誌. 2021. 63. 6-E. 658-658
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今澤 俊之, 北村 博司, 久保田 浩之, 鏑木 康志. 腎診療におけるビッグデータ:何のために何ができる? 腎疾患における多層的オミックス解析研究の展望. 日本腎臓学会誌. 2020. 62. 6. 508-508
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美甘 周史, 姜 美子, 野呂 眞人, 鈴木 康夫, 蛭田 啓之, 久保田 浩之, 武城 英明. 心外膜脂肪と皮下脂肪組織は、褐色化遺伝子発現および減量に対する感受性が異なる. The Lipid. 2019. 30. 2. 227-227
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Patents (2)：
Books (2)：
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AGEsと老化 : 糖化制御からみたウェルエイジング
メディカルレビュー社 2013 ISBN:9784779210051
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糖化による疾患と抗糖化食品・素材
シーエムシー出版 2010 ISBN:9784781302942
Lectures and oral presentations (108)：
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Independent risk factors of rapid renal function decline in patients with type 2 diabetes with preserved kidney function
(International Diabetes Federation Western Pacific Congress 2023 / 15th Asian Association for the Study of Diabetes Scientific Meeting 2023)
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EXPLORATION OF PROGNOSTIC FACTORS IN DIABETIC NEPHROPATHY WITH NODULAR LESION USING TRANSCRIPTOME ANALYSIS OF HUMAN KIDNEY TISSUES
(60th European Renal Association Congress)
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Evaluation of artus SARS-CoV-2 Prep&Amp UM Kit for SARS-CoV-2 Detection, a rapid direct PCR method for the diagnosis of COVID-19
(33rd European Congress of Clinical Microbiology & Infectious Diseases)
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Transcriptome analysis of human kidney tissues to explore prognostic factors in diabetic kidney disease with nodular lesion
(ASN Kidney Week 2022)
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ラット初代培養ポドサイトを用いた 低出生体重関連巣状分節性糸球体硬化症の発症機序解明
(第65回日本腎臓学会学術総会 2022)
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Work history (1)：
- 2010/01 - 現在 National Center for Global Health and Medicine
Association Membership(s) (2)：
一般社団法人 日本腎臓学会
, 一般社団法人日本糖尿病学会
