Rchr
J-GLOBAL ID：202101016798441962   Update date: Nov. 12, 2024

Tominari Tsukasa

トミナリ ツカサ | Tominari Tsukasa
Affiliation and department：
National Center of Neurology and Psychiatry Department of Molecular Therapy, National Institute of Neuroscience, Ncnp

About National Center of Neurology and Psychiatry Department of Molecular Therapy, National Institute of Neuroscience, Ncnp


Job title： Section Chief
Research field  (4)： Laboratory animal science ,  Food sciences ,  Cell biology ,  Molecular biology
Research keywords  (10)： RNA therapeutics ,  Oligonucleotide therapeutics ,  Duchenne muscular dystrophy ,  Amyotrophic lateral sclerosis ,  Muscle metabolism ,  Bone metabolism ,  Disuse muscle atrophy ,  Periodontal disease ,  Osteoporosis ,  Imaging mass spectrometry
Research theme for competitive and other funds  (3)：
  • 2023 - 2026 Basic research on Muse cell transplantation for Duchenne muscular dystrophy
  • 2023 - 2025 Sequence determination and structural optimization of myotropic siRNA for MyoD1 converted urine-derived cells from amyotrophic lateral sclerosis patients
  • 2019 - 2023 骨転移性がんの移動・浸潤におけるコラーゲン代謝の解明と治療薬創出
Papers (35)：
  • Kei Urano, Yuki Tanaka, Tsukasa Tominari, Masaru Takatoya, Daichi Arai, Shinji Miyata, Chiho Matsumoto, Chisato Miyaura, Yukihiro Numabe, Yoshifumi Itoh, et al. The stiffness and collagen control differentiation of osteoclasts with an altered expression of c-Src in podosome. Biochemical and Biophysical Research Communications. 2024
  • Tsukasa Tominari, Masaru Takatoya, Toshiya Matsubara, Michio Matsunobe, Daichi Arai, Chiho Matsumoto, Michiko Hirata, Shosei Yoshinouchi, Chisato Miyaura, Yoshifumi Itoh, et al. Establishment of a Triple Quadrupole HPLC-MS Quantitation Method for Dystrophin Protein in Mouse and Human Skeletal Muscle. International Journal of Molecular Sciences. 2023
  • Michiko Hirata, Tsukasa Tominari, Ryota Ichimaru, Naruhiko Takiguchi, Yuki Tanaka, Masaru Takatoya, Daichi Arai, Shosei Yoshinouchi, Chisato Miyaura, Chiho Matsumoto, et al. Effects of 4′-Demethylnobiletin and 4′-Demethyltangeretin on Osteoclast Differentiation In Vitro and in a Mouse Model of Estrogen-Deficient Bone Resorption. Nutrients. 2023. 15. 6. 1403-1403
  • Shosei Yoshinouchi, Kento Karouji, Tsukasa Tominari, Moe Sugasaki, Chiho Matsumoto, Chisato Miyaura, Michiko Hirata, Yoshifumi Itoh, Masaki Inada. Prostate cancer expressing membrane-bound TGF-α induces bone formation mediated by the autocrine effect of prostaglandin E2 in osteoblasts. Biochemical and biophysical research communications. 2022. 644. 40-48
  • Ryo Tanaka, Shosei Yoshinouchi, Kento Karouji, Yuki Tanaka, Tsukasa Tominari, Michiko Hirata, Chiho Matsumoto, Yoshifumi Itoh, Chisato Miyaura, Masaki Inada. A mouse model of lung cancer induced via intranasal injection for anti-cancer drug screening and evaluation of pathology. FEBS open bio. 2022
ｍore...
MISC (26)：
  • Masaru Takatoya, Tsukasa Tominari, Daichi Arai, Yuki Tanaka, Kento Karouji, Keisuke Ikeda, Kensuke Shimizu, Chisato Miyaura, Michiko Hirata, Masaki Inada. Functional regulation of L-leucine supplementation and mechanical stress on skeletal muscle cells. Functional Food Research. 2024. 20. 49-54
  • Yuki Tanaka, Tsukasa Tominari, Moe Sugasaki, Urara Kasuga, Chiho Matsumoto, Chisato Miyaura, Michiko Hirata, Masaki Inada. Dual effects of lutein on bone metabolism. Functional Food Research. 2024. 20. 41-48
  • Kensuke Shimizu, Yuki Tanaka, Tsukasa Tominari, Keisuke Ikeda, Chisato Miyaura, Michiko Hirata, Masaki Inada. Regulation of bone metabolism by omega-3 fatty acids. Functional Food Research. 2024. 20. 35-40
  • Tsukasa Tominari, Yoshitsugu Aoki. Cutting-edge therapeutic approaches for Duchenne muscular dystrophy. Functional Food Research. 2024. 20. 11-17
  • Tsukasa Tominari, Yoshitsugu Aoki. Cutting-edge therapeutic approaches for Duchenne muscular dystrophy. 2024. 41. 3. 425-430
ｍore...
Lectures and oral presentations  (119)：
  • Gene-transcriptome analysis of hypertrophic skeletal muscles induced by 2 g hypergravity in mice
    (Joint Conference of The 22nd Annual Meeting of Asian and Oceanian Myology Center and The 10th Annual Meeting of Japan Muscle Society 2024)
  • Reactive oxygen species related DNA damage induced cellular senescence in myoblasts
    (Joint Conference of The 22nd Annual Meeting of Asian and Oceanian Myology Center and The 10th Annual Meeting of Japan Muscle Society 2024)
  • Prostaglandin J inhibited cellular proliferation and differentiation in myoblast via reprograming into adipocyte
    (Joint Conference of The 22nd Annual Meeting of Asian and Oceanian Myology Center and The 10th Annual Meeting of Japan Muscle Society 2024)
  • PGE2-induced TGF-β1 mediates epithelial-mesenchymal transition in bone metastatic prostate cancer
    (The 42st Annual Meeting of the Japanese Society for Bone and Mineral Research 2024)
  • Reactive oxygen species regulate differentiation and apoptosis of osteoclasts through MKP-1/MAPK signaling
    (The 42st Annual Meeting of the Japanese Society for Bone and Mineral Research 2024)
ｍore...
Works (4)：
  • NCNP遺伝子疾患治療研究部ホームページ・リデザイン
    2023 -
  • Emblem design of Rare Disease Consortium Japan
    Tsukasa Tominari 2023 - 2023
  • Emblem design of Molecular Therapy, NCNP
    Tsukasa Tominari 2023 - 2023
  • 東京農工大学工学府生命工学専攻稲田研究室ホームページデザイン制作
    2022 -
Education (2)：
  • - 2014 Joint Graduate School of Tokyo University of Agriculture and Technology and Waseda University Cooperative Major in Advanced Health Science
  • 2012 - 2014 University of Bonn Life & medical sciences institute (LIMES)
Professional career (1)：
  • Ph.D. in Life Science (Tokyo University of Agriculture and Technology, Waseda University)
Work history (10)：
  • 2023/07 - 現在 National Center of Neurology and Psychiatry Department of Molecular Therapy, National Institute of Neuroscience Section Chief
  • 2022/04 - 2023/06 National Center of Neurology and Psychiatry Deparment of Moluclar Therapy, National Institute of Neuroscience Research Fellow
  • 2017/04 - 2022/03 Tokyo University of Agriculture and Technology Graduate School of Engineering Department of Biotechnology and Life Science Assistant professor
  • 2014/10 - 2017/03 Tokyo University of Agriculture and Technology Global Innovation Research Organization Assistant professor
  • 2014/04 - 2014/09 Tokyo University of Agriculture and Technology Graduate School of Engineering Department of Biotechnology and Life Science Assistant professor
Show all
Committee career (2)：
  • 2023/06 - 現在 FEBS Open Bio Peer Review Taskforce
  • 2022/07 - 現在 FEBS PRESS Editorial Advisory Board
Awards (2)：
  • 2022/01 - Excellent Paper Award
  • 2020/01 - 第16回ファンクショナルフード学会学術集会 若手研究者 最優秀演題賞 質量分析イメージング法を活用した農水産物における機能性成分の分布解析
Association Membership(s) (8)：
ファンクショナルフード学会 ,  Japan Muscle Society ,  Japan Society of Nutrition and Food Science ,  The American Society for Bone and Mineral Research ,  The Japanise Society for Bone and Mineral Research ,  Japanese Society of Osteoimmunology ,  The Mass Spectrometry Society of Japan ,  The Japanese Biochemical Society
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