Sugawara Sho

Research keywords (5)： Cellular Senescence , SASP , Cancer , ミトコンドリア , 脂肪細胞

Research theme for competitive and other funds (3)：

2023 - 2026 Elucidation of the mechanisms of SASP induction and cancer promotion through translational regulation in senescent CAFs
2021 - 2024 老化細胞におけるDNA/RNAハイブリッドを介したがん促進機構の解明
2018 - 2020 脂肪細胞におけるミトコンドリアを介したエネルギー代謝機構の解明

Papers (5)：

Hisamichi Tanaka, Sho Sugawara, Yoko Tanaka, Tze Mun Loo, Ryo Tachibana, Atsuki Abe, Mako Kamiya, Yasuteru Urano, Akiko Takahashi. Dipeptidylpeptidase-4-targeted activatable fluorescent probes visualize senescent cells. Cancer Science. 2024. 115. 8. 2762-2773
Sho Sugawara, Ryo Okada, Tze Mun Loo, Hisamichi Tanaka, Kenichi Miyata, Masatomo Chiba, Hiroko Kawasaki, Kaoru Katoh, Shizuo Kaji, Yoshiro Maezawa, et al. RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells. Communications Biology. 2022. 5. 1. 1420-1420
Sho Sugawara, Yusuke Kanamaru, Shiori Sekine, Lila Maekawa, Akinori Takahashi, Tadashi Yamamoto, Kengo Watanabe, Takao Fujisawa, Kazuki Hattori, Hidenori Ichijo. The mitochondrial protein PGAM5 suppresses energy consumption in brown adipocytes by repressing expression of uncoupling protein 1. The Journal of biological chemistry. 2020. 295. 17. 5588-5601
Kazuki Hattori, Hiroaki Wakatsuki, Chihiro Sakauchi, Shotaro Furutani, Sho Sugawara, Tomohisa Hatta, Tohru Natsume, Hidenori Ichijo. β-adrenergic receptor signaling evokes the PKA-ASK axis in mature brown adipocytes. PloS one. 2020. 15. 10. e0232645
Shiori Sekine, Akari Yao, Kazuki Hattori, Sho Sugawara, Isao Naguro, Masato Koike, Yasuo Uchiyama, Kohsuke Takeda, Hidenori Ichijo. The Ablation of Mitochondrial Protein Phosphatase Pgam5 Confers Resistance Against Metabolic Stress. EBioMedicine. 2016. 5. 82-92

MISC (5)：

日浦伸宏, 早川智久, 菅原祥, 高橋暁子. 細胞老化の多様性. 日本臨床特集「老化と疾患-エイジング研究の進歩-」. 2024. 81. 4. 101-107
Sho Sugawara, Masatomo Chiba, Akiko Takahashi. Cellular Senescence and Cancer Research and its Development into Regenerative Medicine. REGENERATIVE MEDICINE. 2022. 21. 2. 80-87
菅原祥, 宮田憲一, 田中久通, 高橋暁子. 老化現象とバイオマテリアル老化研究と細胞老化の基礎. バイオマテリアル(Web). 2020. 38. 3
高橋暁子, 宮田憲一, 羅智文, 菅原祥. The Analysis of Epigenetic alteration in cellular senescence and cancer. 日本癌学会学術総会抄録集(Web). 2020. 79th
LOO Tze Mun, 菅原祥, 高橋暁子. Biofunctional analysis of SASP factors. 月刊老年内科. 2020. 2. 6

Education (2)：

2014 - 2019 The University of Tokyo Graduate School of Pharmaceutical Sciences Department of Pharmaceutical Sciences
2010 - 2014 Kitasato University School of Pharmaceutical Sciences

Work history (5)：

2024/04 - 現在 Japanese Foundation for Cancer Research
2021/04 - 2024/03 Japan Society for the Promotion of Science
2020/04 - 2021/03 Japanese Foundation for Cancer Research Project for Cellular Senescence, The Cancer Institute
2019/04 - 2020/03 Japan Society for the Promotion of Science
2018/04 - 2019/03 Japan Society for the Promotion of Science

Awards (3)：

2019/04 - 第19回東京大学生命科学シンポジウム優秀ポスター賞 PGAM5による褐色脂肪細胞の機能制御解析
2018/06 - 第10回シグナルネットワーク研究会奨励賞ミトコンドリア局在型プロテインホスファターゼPGAM5の細胞・個体レベルでの生理機能解析
2016/11 - 第39回日本分子生物学会年会優秀ポスター賞ミトコンドリア内膜局在型プロテインホスファターゼPGAM5の細胞レベル・個体レベルでの生理機能解析

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