Arisawa Kotoko

Affiliation and department：

Research field (1)： Food sciences

Research theme for competitive and other funds (8)：

2024 - 2028 Elucidation of the molecular pathology of chronic diseases and establishment of new treatment methods based on trace element research
2024 - 2027 セレン輸送体による新たな鉄代謝制御システムの解明と肝疾患治療への応用
2022 - 2024 Mechanisms of liver disease pathogenesis based on selenium homeostasis in the liver
2021 - 2024 酸化コレステロールによる生体膜脂質組成の調節を介した代謝性疾患増悪のメカニズム
2020 - 2024 Regulatory mechanism of selenoprotein P expression and its deterioration mechanism of glucose metabolism

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Papers (12)：

Xinying Ye, Takashi Toyama, Wang Yinuo, Runa Kudo, Siu Stephanie, Kotoko Arisawa, Yoshiro Saito. Inhibition of Selenium Supply Function of Selenoprotein P through Adduct Formation by Sulforaphane. The Journal of nutritional biochemistry. 2024. 109781-109781
Xi Zheng, Takashi Toyama, Stephanie Siu, Takayuki Kaneko, Hikari Sugiura, Shota Yamashita, Yoshiteru Shimoda, Masayuki Kanamori, Kotoko Arisawa, Hidenori Endo, et al. Selenoprotein P expression in glioblastoma as a regulator of ferroptosis sensitivity: preservation of GPX4 via the cycling-selenium storage. Scientific Reports. 2024. 14. 1
Kotoko Arisawa, Ayumi Matsuoka, Natsuki Ozawa, Tomoko Ishikawa, Ikuyo Ichi, Yoko Fujiwara. GPER/PKA-Dependent Enhancement of Hormone-Sensitive Lipase Phosphorylation in 3T3-L1 Adipocytes by Piceatannol. Nutrients. 2023. 16. 1. 38
Xinying Ye, Takashi Toyama, Keiko Taguchi, Kotoko Arisawa, Takayuki Kaneko, Ryouhei Tsutsumi, Masayuki Yamamoto, Yoshiro Saito. Sulforaphane decreases serum selenoprotein P levels through enhancement of lysosomal degradation independent of Nrf2. Communications Biology. 2023. 6. 1
Ayako Mizuno, Takashi Toyama, Atsuya Ichikawa, Naoko Sakai, Yuya Yoshioka, Yukina Nishito, Renya Toga, Hiroshi Amesaka, Takayuki Kaneko, Kotoko Arisawa, et al. An efficient selenium transport pathway of selenoprotein P utilizing a high-affinity ApoER2 receptor variant and being independent of selenocysteine lyase. Journal of Biological Chemistry. 2023. 299. 8. 105009-105009

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MISC (4)：

有澤琴子, 外山喬士, 斎藤芳郎. スルフォラファンによるセレノプロテインP抑制と糖尿病予防への可能性. 『機能性食品と薬理栄養』日本機能性食品医用学会誌. 2024. 18. 1. 29-34
有澤琴子, 外山喬士, 斎藤芳郎. 必須微量元素セレン研究の最前線-ダイナミクスと生理/病理的意義,重金属毒性に対する作用. ファルマシア. 2023. 59. 3. 179-184
Effects of Selenium and Vitamin E on Ferroptosis, a Form of Cell Death Associated with Iron-dependent Lipid Peroxidation : Mechanism of Novel Programmed Cell Death "Ferroptosis". 2022. 60. 11. 573-580
ARISAWA Kotoko, ICHI Ikuyo. Lipid Droplet Membrane Protein and Monolayer Lipid Membranes Are Regulators of the Lipid Droplet Size: The Characterizations of Lipid Droplet Surface Decide the Size of Lipid Droplet. KAGAKU TO SEIBUTSU. 2018. 56. 4. 248-254

Books (2)：

Lectures and oral presentations (15)：

セレノプロテインPによる細胞内セレン代謝変動を介したフェロトーシス制御機構
(第51回日本毒性学会学術年会 2024)
炎症によるセレン代謝抑制機構の解析と生理的意義
(第50回生体分子科学討論会・第3回生命金属科学シンポジウム 2024)
セレン輸送タンパク質Selenoprotein Pを介した肝セレン動態およびフェロトーシスの制御
(日本薬学会第144年会 2024)
Gタンパク質共役エストロゲン受容体の活性化を介したピセアタンノールの抗肥満効果
(2024年度日本農芸化学会東京大会 2024)
肝細胞癌におけるセレノプロテインP発現変動の意義
(第7回日本セレン研究会 2024)

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Education (3)：

2014 - 2017 Ochanomizu University Graduate School of Humanities and Sciences Life Sciences
2012 - 2014 Ochanomizu University Graduate School of Humanities and Sciences Life Sciences
2008 - 2012 Ochanomizu University Faculty of Human Life and Environmental Sciences Division of Nutrition and Food Science

Professional career (1)：

Work history (7)：

2021/07 - 現在 Tohoku University Faculty of Pharmaceutical Sciences
2022/04 - 2022/08 Ibaraki University College of Education
2021/04 - 2021/06 Ochanomizu University Faculty of Human Life and Environmental Sciences Division of Nutrition and Food Science
2020/10 - 2021/03 松戸市立総合医療センター附属看護専門学校非常勤講師
2020/04 - 2021/03 Ochanomizu University Faculty of Human Life and Environmental Sciences Division of Nutrition and Food Science

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Awards (1)：

2022/12 - 22nd IUNS-ICN International Congress of Nutrition (22nd IUNS-ICN) Young Investigator Excellent Abstract Award

Association Membership(s) (4)：

日本毒性学会 , 日本薬学会 , 日本栄養・食糧学会 , 日本農芸化学会

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