Rchr
J-GLOBAL ID：202101019958568106   Update date: Oct. 31, 2024

MIYACHI HIROYUKI

ミヤチ ヒロユキ | MIYACHI HIROYUKI
Affiliation and department：
The University of Tokyo

About The University of Tokyo


Research theme for competitive and other funds  (5)：
  • 2015 - 2016 宿主脂質動態制御に基づくC型肝炎治療の化学基盤
  • 2014 - 2016 ビス(ビベンジル)型天然物は新たな膜障害性抗MRSA薬となり得るか!
  • 2013 - 2016 シナプス伝達におけるグルタミン酸充填量制御メカニズムの構造生物学的解明とその応用
  • 2011 - 2013 Explolation of gamma-secretase modulator based on metabolic nuclear receptor
  • 2002 - 2006 Design and development of biological response modifiers
Papers (122)：
  • hiroyuki miyachi. Structural Biology Inspired Development of a Series of Human Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Ligands: From Agonist to Antagonist. International Journal of Molecular Sciences. 2023
  • Mami Yoshizawa, Tomomi Aoyama, Toshimasa Itoh, Hiroyuki Miyachi. Arylalkynyl amide-type peroxisome proliferator-activated receptor γ (PPARγ)-selective antagonists covalently bind to the PPARγ ligand binding domain with a unique binding mode. Bioorganic & medicinal chemistry letters. 2022. 64. 128676-128676
  • Takuji Oyama, Kazuki Takiguchi, Hiroyuki Miyachi. Crystal structures of the ligand-binding domain of human peroxisome proliferator-activated receptor δ in complexes with phenylpropanoic acid derivatives and a pyridine carboxylic acid derivative. Acta crystallographica. Section F, Structural biology communications. 2022. 78. Pt 2. 81-87
  • Hiroyuki Miyachi. Structural Biology-Based Exploration of Subtype-Selective Agonists for Peroxisome Proliferator-Activated Receptors. International journal of molecular sciences. 2021. 22. 17
  • Hiroyuki Miyachi, Kayoko Kanamitsu, Mayumi Ishii, Eri Watanabe, Akira Katsuyama, Satoko Otsuguro, Fumika Yakushiji, Mizuki Watanabe, Kouhei Matsui, Yukina Sato, et al. Structure, solubility, and permeability relationships in a diverse middle molecule library. Bioorganic & medicinal chemistry letters. 2021. 37. 127847-127847
ｍore...
MISC (59)：
  • Miyachi Hiroyuki, Yasuda Kosuke, Kanamitsu Kayoko, Kurebayashi Yoichi. Forefront of the academic drug discovery hit to lead support: history of the Lead Exploration Unit, Drug Discovery Initiative, The University of Tokyo. MEDCHEM NEWS. 2021. 31. 1. 13-16
  • 宮地 弘幸. 低分子医薬品今昔. 化学と教育. 2020. 68. 7. 282-285
  • 宮地弘幸, 布村一人, LIN Bangzhong, 土井健史, 橘敬祐. Identification of nobel human peroxisome proliferator-activated receptor alpha-selective agonists and its structural development. 日本薬学会年会要旨集(CD-ROM). 2020. 140th (Web)
  • 松尾和哉, 矢吹悌, 程岸, 篠田康晴, 宮地弘幸, 福永浩司. 脂肪酸結合タンパク質を介したα-synuclein毒性発現と創薬. 日本薬理学雑誌. 2020. 155. Supplement
  • Matsuo Kazuya, Yabuki Yasushi, Izumi Hisanao, Shinoda Yasuharu, Miyachi Hiroyuki, Fukunaga Kohji. Fatty acid-binding protein ligands inhibit α-synuclein pathology in Parkinsonian mice. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2019. 92. 1-SS-72
ｍore...
Work history (4)：
  • 2022/04 - 東京大学大学院薬学系研究科附属創薬機構 構造展開ユニット 特任教授
  • 2016/04 - 2021/03 The University of Tokyo
  • 2009/10 - 2016/03 Okayama University Graduate School of Medicine , Dentistry and Pharmaceutical Sciences
  • 2004/04 - 2009/09 The University of Tokyo Institute of Molecular and Cellular Biosciences
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