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J-GLOBAL ID：202102210982885810   Reference number：21A0325808

The Use of Translucent Skin Mutants of the Silkworm “o06” Strain as a Model of Hyperuricemia Based on Analysis of Uric Acid Metabolism

尿酸代謝分析に基づいた高尿酸血症モデルとしてのカイコ「o06」系統の半透明皮膚変異体の使用

Author (9)： TANAKA Ryuichiro (Setsunan Univ., Osaka, JPN) ,  NISHIKUBO Nanae (Setsunan Univ., Osaka, JPN) ,  SUETOMI Shohei (Setsunan Univ., Osaka, JPN) ,  HOSOKI Miku (Setsunan Univ., Osaka, JPN) ,  KAWAKAMI Hikaru (Setsunan Univ., Osaka, JPN) ,  MASUDA Hiroto (Setsunan Univ., Osaka, JPN) ,  YAMAGUCHI Shoji (Setsunan Univ., Osaka, JPN) ,  BANNO Yutaka (Kyusyu Univ., Fukuoka, JPN) ,  SAKAZAKI Fumitoshi (Osaka Ohtani Univ., Osaka, JPN)
Material： Alternatives to Animal Testing and Experimentation  (AATEX)
Volume： 25  Issue： 1  Page： 1-12  Publication year： Nov. 30, 2020 
JST Material Number： L5507A  ISSN： 1344-0411  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *silkworm ,...
Semi thesaurus term： Animal Use Alternatives ,...

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JST classification (3)： Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Animal metabolism and nutrition in general  (EJ02031R) ,  Blood in general  (EJ03010L)

Substance index (5)： Allopurinol ,  Uric Acid ,  Febuxostat ,  FYX-051 ,  Allantoin

Reference (16)：

• (1993), Japan Society of Clinical Chemistry, Recommended method for determination of uric acid in serum by HPLC. Clinical Chemistry 22, 300-307.
• Eguchi M. (1961) Relation between uric acid content and xanthine dehydrogenase activity in several translucent and normal silkworms, Japanese J. Appl. Entomol. Zool., 5, 163-166.
• Hamamoto H., and Sekimizu K. (2014) Silkworm as a model animal for drug development, SEIKAGAKU, 86, 578-582.
• Hayashi Y. (1960) Xanthine dehydrogenase in the silkworm, Bombyx mori L. Nature, 186, 1053- 1054.
• Hiroshige K., Kunifuji Y., Takasugi M., and Kuroiwa A. (1992) Studies on purine- pyrimidine metabolism (1) Quantitation of purine-pyrimidine metabolites and allopurinol- oxipurinol in biological fluids, J UOEH. 14, 211-218.

Terms in the title (9)： 尿酸代謝 ,  分析 ,  高尿酸血症 ,  モデル ,  カイコ ,  系統 ,  半透明 ,  皮膚 ,  変異体