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J-GLOBAL ID：202102211085804694   Reference number：21A0168780

Cathepsin G-Induced Insulin-Like Growth Factor (IGF) Elevation in MCF-7 Medium Is Caused by Proteolysis of IGF Binding Protein (IGFBP)-2 but Not of IGF-1

MCF-7培地におけるカテプシンG誘導インシュリン様成長因子(IGF)上昇はIGF-1ではなくIGF結合蛋白質(IGFBP)2の分解により惹起される

Author (3)： Morimoto-Kamata Riyo (Laboratory of Host Defense, Faculty of Pharma-Science, Teikyo University) ,  Tsuji Daiki (Laboratory of Host Defense, Faculty of Pharma-Science, Teikyo University) ,  Yui Satoru (Laboratory of Host Defense, Faculty of Pharma-Science, Teikyo University)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 43  Issue： 11  Page： 1678-1686(J-STAGE)  Publication year： 2020 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： MCF7 cell ,...
Semi thesaurus term： IGF受容体1 ,...

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Author keywords (10)： cathepsin G ,  breast cancer ,  insulin-like growth factor-1 ,  insulin-like growth factor binding protein ,  serine protease ,  cathepsin G ,  breast cancer ,  insulin-like growth factor-1 ,  insulin-like growth factor binding protein ,  serine protease

JST classification (2)： Basic oncology in general  (GE02010R) ,  Cell physiology in general  (EF02010S)

Reference (47)：

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• 3) Powell DR, Huttenlocher A. Neutrophils in the tumor microenvironment. Trends Immunol., 37, 41-52 (2016).
• 4) Kim J, Bae JS. Tumor-associated macrophages and neutrophils in tumor microenvironment. Mediators Inflamm., 2016, 6058147 (2016).
• 5) Shaul ME, Fridlender ZG. Cancer-related circulating and tumor-associated neutrophils-subtypes, sources and function. FEBS J., 285, 4316-4342 (2018).

Terms in the title (8)： MCF-7 ,  培地 ,  カテプシンG ,  誘導 ,  インシュリン様成長因子 ,  IGF結合蛋白質 ,  IGFBP ,  分解