Art

J-GLOBAL ID：202102211791073263   Reference number：21A0037082

Melatonin Suppresses Ferroptosis Induced by High Glucose via Activation of the Nrf2/HO-1 Signaling Pathway in Type 2 Diabetic Osteoporosis

メラトニンは2型糖尿病骨粗鬆症におけるNrf2/HO-1シグナル伝達経路の活性化を介して高グルコースによって誘発されるフェロトーシスを抑制する【JST・京大機械翻訳】

Author (7)： Ma Hongdong (Department of Orthopedics, The First Hospital of China Medical University, Shenyang, Liaoning, China) ,  Wang Xindong (Department of Orthopedics, The First Hospital of China Medical University, Shenyang, Liaoning, China) ,  Zhang Weilin (Department of Orthopedics, The Fourth Hospital of China Medical University, Shenyang, Liaoning, China) ,  Li Haitian (Department of Orthopedics, The First Hospital of China Medical University, Shenyang, Liaoning, China) ,  Zhao Wei (Department of Orthopedics, The Fourth Hospital of China Medical University, Shenyang, Liaoning, China) ,  Sun Jun (Department of Orthopedics, The Third Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China) ,  Yang Maowei (Department of Orthopedics, The First Hospital of China Medical University, Shenyang, Liaoning, China)
Material： Oxidative Medicine and Cellular Longevity (Web)  (Oxidative Med Cell Longev (Web))
Volume： 2020  Page： Null  Publication year： 2020 
JST Material Number： U7012A  ISSN： 1942-0900  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Ferroptosis is recently identi...

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Thesaurus term： *iron ,  alkaline phosphatase ,  osteogenesis ,  protein ,  mitochondria ,  rat ,  *osteoporosis ,  in vivo experiment ,  in vitro experiment ,  osteoblast ,  pathogenesis ,  hexose ,  aldose ,  fatty acid ,  nitrogen heterocyclic compound ,  carboxamide ,  phenol ether ,  polynuclear aromatic compound
Semi thesaurus term： オステオカルシン ,  *NFE2関連因子2 , 【Automatic Indexing@JST】

JST classification (5)： Basic research of pharmacology of crude drugs  (GX06020J) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Basic research of drugs acting on carbohydrate metabolism  (GW13020Q) ,  Plant biochemistry  (EH01050J) ,  Cell physiology in general  (EF02010S)

Substance index (2)： Glucose ,  Melatonin

Reference (58)：

• W. Rathmann, K. Kostev, "Fracture risk in patients with newly diagnosed type 2 diabetes: a retrospective database analysis in primary care," Journal of Diabetes and its Complications, vol. 29, no. 6, pp. 766-770, 2015.
• P. Vestergaard, "Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes-a meta-analysis," Osteoporosis International, vol. 18, no. 4, pp. 427-444, 2007.
• N. Napoli, E. S. Strotmeyer, K. E. Ensrud, D. E. Sellmeyer, D. C. Bauer, A. R. Hoffman, T. T. L. Dam, E. Barrett-Connor, L. Palermo, E. S. Orwoll, S. R. Cummings, D. M. Black, A. V. Schwartz, "Fracture risk in diabetic elderly men: the MrOS study," Diabetologia, vol. 57, no. 10, pp. 2057-2065, 2014.
• C. Adil, T. Aydın, Ö. Taşpınar, H. Kızıltan, A. H. Eriş, I. T. Hocaoglu, S. Poşul, M. Kepekci, E. Denizli, M. Güler, "Bone mineral density evaluation of patients with type 2 diabetes mellitus," Journal of Physical Therapy Science, vol. 27, no. 1, pp. 179-182, 2015.
• P. Pietschmann, J. M. Patsch, G. Schernthaner, "Diabetes and bone," Hormone & Metabolic Research, vol. 42, no. 11, pp. 763-768, 2010.

Terms in the title (10)： メラトニン ,  2型糖尿病 ,  骨粗鬆症 ,  NRF2 ,  HO-1 ,  シグナル伝達経路 ,  活性化 ,  グルコース ,  誘発 ,  フェロトーシス