Art

J-GLOBAL ID：202102215694878379   Reference number：21A0091905

Amino acid-dependent control of mTORC1 signaling: a variety of regulatory modes

mTORC1シグナル伝達のアミノ酸依存性制御:調節様式の多様性【JST・京大機械翻訳】

Author (5)： Takahara Terunao (Department of Applied Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan) ,  Amemiya Yuna (Department of Applied Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan) ,  Sugiyama Risa (Department of Applied Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan) ,  Maki Masatoshi (Department of Applied Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan) ,  Shibata Hideki (Department of Applied Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan)
Material： Journal of Biomedical Science (Web)
Volume： 27  Issue： 1  Page： 1-16  Publication year： 2020 
JST Material Number： U7325A  ISSN： 1423-0127  Document type： Article
Article type： 文献レビュー  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： The mechanistic target of rapa...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=21A0091905&from=J-GLOBAL&jstjournalNo=U7325A") }}

Thesaurus term： *amino acid ,  protein ,  diabetes mellitus ,  cell proliferation ,  complex(substance) ,  lipogenesis ,  lysosome ,  GTPase ,  growth factor ,  *cellular signal transduction ,  autophagy ,  aliphatic amine ,  aliphatic carboxylic acid ,  branched-chain amino acid ,  primary amine
Semi thesaurus term： 神経変性疾患 ,  *mTORC1 , 【Automatic Indexing@JST】

Author keywords (6)： mTOR ,  mTORC1 ,  Amino acids ,  Rag GTPases ,  Rheb GTPase ,  Intracellular Ca2+ concentration

JST classification (2)： Cell physiology in general  (EF02010S) ,  Biological function  (EB03040U)

Substance index (2)： Leucine ,  Arginine

Reference (162)：

• Heitman J, Movva NR, Hall MN. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science. 1991;253:905-9.
• Cell.; TOR signaling in growth and metabolism; S Wullschleger, R Loewith, MN Hall; 124; 2006; 471-484; citation_id=CR2
• J Biol Chem; Nutrient-dependent multimerization of the mammalian target of rapamycin through the N-terminal HEAT repeat region; T Takahara, K Hara, K Yonezawa, H Sorimachi, T Maeda; 281; 2006; 28605-28614; citation_id=CR3
• Genetics.; Drosophila target of rapamycin kinase functions as a multimer; Y Zhang, CJ Billington, D Pan, TP Neufeld; 172; 2006; 355-362; citation_id=CR4
• J Biol Chem; Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1; L Wang, CJ Rhodes, JC Lawrence; 281; 2006; 24293-24303; citation_id=CR5

Terms in the title (7)： mTORC1 ,  シグナル伝達 ,  アミノ酸 ,  依存性 ,  調節 ,  様式 ,  多様性