Art

J-GLOBAL ID：202102216493061246   Reference number：21A0723131

Mitochondrial Dysfunction and DNA Damage in the Context of Pathogenesis of Atherosclerosis

アテローム性動脈硬化症の病因の文脈におけるミトコンドリア機能障害とDNA損傷【JST・京大機械翻訳】

Author (7)： Shemiakova Taisiia (Institute of Translational Biomedicine, St. Petersburg State University, 199034 St. Petersburg, Russia) ,  Ivanova Ekaterina (Department of Basic Research, Institute for Atherosclerosis Research, 121609 Moscow, Russia) ,  Grechko Andrey V. (Federal Scientific Clinical Center for Resuscitation and Rehabilitation, 109240 Moscow, Russia) ,  Gerasimova Elena V. (Laboratory of Systemic Rheumatic Disorders, V.A. Nasonova Institute of Rheumatology, 115522 Moscow, Russia) ,  Sobenin Igor A. (Laboratory of Medical Genetics, Institute of Experimental Cardiology, National Medical Research Center of Cardiology, 121552 Moscow, Russia) ,  Orekhov Alexander N. (Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia) ,  Orekhov Alexander N. (Laboratory of Infection Pathology and Molecular Microecology, Institute of Human Morphology, 117418 Moscow, Russia)
Material： Biomedicines (Web)
Volume： 8  Issue： 6  Page： 166  Publication year： 2020 
JST Material Number： U7146A  ISSN： 2227-9059  Document type： Article
Article type： 文献レビュー  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Atherosclerosis is a multifact...

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Thesaurus term： plasma(blood) ,  inflammation ,  smoking(tobacco) ,  diabetes mellitus ,  *mitochondria ,  targeting ,  *atherosclerosis ,  *DNA lesion ,  oxidative stress ,  *pathogenesis
Semi thesaurus term： ミトコンドリアDNA ,  抗酸化剤 ,  分子機構 ,  *ミトコンドリア機能障害 ,  *ミトコンドリア機能 , 【Automatic Indexing@JST】

Author keywords (7)： atherosclerosis ,  mitochondrial dysfunction ,  mtDNA damage ,  oxidative stress ,  inflammation ,  antioxidants ,  endothelial cells

JST classification (4)： Basic medicine on cardiovascular system  (GJ01020K) ,  Cardiovascular system diseases  (GJ03000C) ,  Vasculature  (EJ04030O) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J)

Reference (79)：

• WHO. Cardiovascular Diseases. Available online: https://www.who.int/health-topics/cardiovascular-diseases/#tab=tab_1 (accessed on 31 May 2020).
• Corina, D.-C. Atherosclerosis in the young adult: Fewer hypotheses, more facts. Med. Surg. J. 2016, 120, 768-776.
• McGill, H.C.; McMahan, A.; Zieske, A.W.; Sloop, G.D.; Walcott, J.F.; Troxclair, D.A.; Malcom, G.T.; Tracey, R.E.; Oalmann, M.C.; Strong, J.P. Pathobiological determinants of atherosclerosis in youth (PDAY) research group associations of coronary heart disease risk factors with the intermediate lesion of atherosclerosis in youth. Arterioscler. Throm. Basc. Biol. 2000, 20, 1998-2004.
• Marchio, P.; Guerra-Ojeda, S.; Vila, J.M.; Aldasoro, M.; Victor, V.M.; Mauricio, M.D. Targeting early atherosclerosis: a focus on oxidative stress and inflammation. Oxid. Med. Cell Longev. 2019, 2019, 8563845.
• Davignon, J.; Ganz, P. Role of endothelial dysfunction in atherosclerosis. Circulation 2004, 109, III-27-III-32.

Terms in the title (5)： アテローム性動脈硬化症 ,  病因 ,  文脈 ,  ミトコンドリア機能障害 ,  DNA損傷