Art

J-GLOBAL ID：202102219905710206   Reference number：21A0470928

Down-regulation of dual-specificity phosphatase 6, a negative regulator of oncogenic ERK signaling, by ACA-28 induces apoptosis in NIH/3T3 cells overexpressing HER2/ErbB2

HER2/ErbB2を過剰発現したNIH/3T3細胞において,ACA-28による発癌性ERKシグナル伝達の負の調節因子である二重特異性ホスファターゼ6のダウンレギュレーションはアポトーシスを誘導する

Author (10)： Kanda Yuki (Laboratory of Molecular Pharmacogenomics, Department of Pharmaceutical Sciences, Kindai University, Higashi-Osaka, Japan) ,  Mizuno Ayami (Laboratory of Molecular Pharmacogenomics, Department of Pharmaceutical Sciences, Kindai University, Higashi-Osaka, Japan) ,  Takasaki Teruaki (Laboratory of Molecular Pharmacogenomics, Department of Pharmaceutical Sciences, Kindai University, Higashi-Osaka, Japan) ,  Satoh Ryosuke (Laboratory of Molecular Pharmacogenomics, Department of Pharmaceutical Sciences, Kindai University, Higashi-Osaka, Japan) ,  Hagihara Kanako (Laboratory of Molecular Pharmacogenomics, Department of Pharmaceutical Sciences, Kindai University, Higashi-Osaka, Japan) ,  Masuko Takashi (Laboratory of Natural Drug Resources, Department of Pharmaceutical Sciences, Kindai University, Higashi-Osaka, Japan) ,  Endo Yuichi (Laboratory of Natural Drug Resources, Department of Pharmaceutical Sciences, Kindai University, Higashi-Osaka, Japan) ,  Tanabe Genzoh (Laboratory of Organic Chemistry, Department of Pharmacy, Kindai University, Higashi-Osaka, Japan) ,  Sugiura Reiko (Laboratory of Molecular Pharmacogenomics, Department of Pharmaceutical Sciences, Kindai University, Higashi-Osaka, Japan) ,  Sugiura Reiko (Pharmaceutical Research and Technology Institute, Kindai University, Higashi-Osaka, Japan)
Material： Genes to Cells  (Genes Cells)
Volume： 26  Issue： 2  Page： 109-116  Publication year： Feb. 2021 
JST Material Number： W0935A  ISSN： 1356-9597  CODEN： GECEFL  Document type： Article
Article type： 短報  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： *serine/threonine specific protein phosphatase ,...
Semi thesaurus term： HER-2 ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=21A0470928&from=J-GLOBAL&jstjournalNo=W0935A") }}

Author keywords (6)： ACA-28 ,  apoptosis ,  cancer treatment ,  dual-specificity phosphatase ,  ERK MAPK ,  proteasome-dependent degradation

JST classification (3)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Cell physiology in general  (EF02010S) ,  Gene expression  (EC02040Q)

Terms in the title (13)： HER2 ,  ErbB2 ,  過剰発現 ,  NIH ,  3T3細胞 ,  発癌性 ,  ERK ,  シグナル伝達 ,  調節因子 ,  二重特異性ホスファターゼ6 ,  ダウンレギュレーション ,  アポトーシス ,  誘導