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J-GLOBAL ID：202102220403546529   Reference number：21A0433614

Improving Thermodynamic Stability and Anticoagulant Activity of a Thrombin Binding Aptamer by Incorporation of 8-trifluoromethyl-2′-deoxyguanosine

8-トリフルオロメチル-2′-デオキシグアノシンの取り込みによるトロンビン結合アプタマーの熱力学的安定性と抗凝固活性の改善【JST・京大機械翻訳】

Author (6)： Bao Hong-Liang (Division of Chemistry, Department of Medical Sciences, Faculty of Medicine, University of Miyazaki, Japan) ,  Ishizuka Takumi (Division of Chemistry, Department of Medical Sciences, Faculty of Medicine, University of Miyazaki, Japan) ,  Yamashita Atsushi (Department of Pathology, Division of Pathophysiology, University of Miyazaki, Japan) ,  Furukoji Eiji (Department of Radiology, Faculty of Medicine, University of Miyazaki, Japan) ,  Asada Yujiro (Department of Pathology, Division of Pathophysiology, University of Miyazaki, Japan) ,  Xu Yan (Division of Chemistry, Department of Medical Sciences, Faculty of Medicine, University of Miyazaki, Japan)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 64  Issue： 1  Page： 711-718  Publication year： 2021 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： In this study, we incorporated...

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Thesaurus term： NMR ,  Electrophoresis ,  circular dichroism ,  melting point ,  anticoagulant ,  *Thrombin ,  nucleoside ,  Rattus ,  prothrombin time ,  thermodynamic stability ,  *anticoagulant action ,  *aptamer ,  G-Quadruplexes ,  Myomorpha

JST classification (3)： Basic research of drugs acting on blood and body fluid  (GW14010M) ,  Synthesis of drugs  (GV01030F) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Terms in the title (6)： 2′-デオキシグアノシン ,  取り込み ,  トロンビン ,  アプタマー ,  熱力学的安定性 ,  抗凝固活性