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J-GLOBAL ID：202102223640473371   Reference number：21A0013982

Activation of the Melanocortin-1 Receptor by NDP-MSH Attenuates Oxidative Stress and Neuronal Apoptosis through PI3K/Akt/Nrf2 Pathway after Intracerebral Hemorrhage in Mice

NDP-MSHによるメラノコルチン-1受容体の活性化はマウスの脳内出血後のPI3K/Akt/Nrf2経路を介して酸化ストレスとニューロンアポトーシスを減弱する【JST・京大機械翻訳】

Author (9)： Fu Siming (Department of Neurosurgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China) ,  Luo Xu (Department of Neurosurgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China) ,  Wu Xuan (Department of Neurosurgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China) ,  Zhang Tongyu (Department of Neurosurgery, Xuanwu Hospital of Capital Medical University, Beijing 100053, China) ,  Gu Linggui (Department of Neurosurgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China) ,  Wang Yiying (Department of Human Anatomy, Chongqing Medical University, Chongqing 400016, China) ,  Gao Meng (Department of Human Anatomy, Chongqing Medical University, Chongqing 400016, China) ,  Cheng Yuan (Department of Neurosurgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China) ,  Xie Zongyi (Department of Neurosurgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China)
Material： Oxidative Medicine and Cellular Longevity (Web)  (Oxidative Med Cell Longev (Web))
Volume： 2020  Page： Null  Publication year： 2020 
JST Material Number： U7012A  ISSN： 1942-0900  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Oxidative stress and neuronal ...

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Thesaurus term： *neuron ,  phosphorylation ,  down-regulation ,  *apoptosis ,  *oxidative stress ,  Western blotting ,  TUNEL method ,  brain damage ,  *phosphatidylinositol 3-kinase ,  siRNA
Semi thesaurus term： アゴニスト ,  *Akt/蛋白質キナーゼB ,  BCL-2 ,  *NFE2関連因子2 , 【Automatic Indexing@JST】

JST classification (2)： Basic research of other drugs acting on central nervous system  (GW03120U) ,  Cell physiology in general  (EF02010S)

Substance index (1)： LY-294002

Reference (49)：

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• R. X. Xie, D. W. Li, X. C. Liu, M. F. Yang, J. Fang, B. L. Sun, Z.-y. Zhang, X. Y. Yang, "Carnosine Attenuates Brain Oxidative Stress and Apoptosis After Intracerebral Hemorrhage in Rats," Neurochemical Research, vol. 42, no. 2, pp. 541-551, 2017.
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Terms in the title (13)： NDP-MSH ,  メラノコルチン ,  受容体 ,  活性化 ,  マウス ,  脳内出血 ,  PI3K ,  Akt ,  NRF2 ,  経路 ,  酸化ストレス ,  ニューロンアポトーシス ,  減弱