Art

J-GLOBAL ID：202102228081783466   Reference number：21A0581057

Current Landscape of NRF2 Biomarkers in Clinical Trials

臨床試験におけるNRF2バイオマーカーの現在の景観【JST・京大機械翻訳】

Author (4)： Yagishita Yoko ,  Gatbonton-Schwager Tonibelle N. ,  McCallum Melissa L. ,  Kensler Thomas W.
Material： Antioxidants (Web)
Volume： 9  Issue： 8  Page： 716  Publication year： 2020 
JST Material Number： U7134A  ISSN： 2076-3921  Document type： Article
Article type： 文献レビュー  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： The transcription factor NF-E2...

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Thesaurus term： optimization ,  inflammation ,  carcinogenesis ,  human(primates) ,  oxidation-reduction reaction ,  *clinical trial ,  homeostasis ,  gene expression ,  cellular signal transduction ,  transcription factor ,  *biomarker ,  oxidative stress ,  immunosuppressant ,  aliphatic carboxylic acid ,  olefin compound ,  unsaturated carboxylic acid ,  carboxylate(ester) ,  dicarboxylic acid
Semi thesaurus term： メタボロミクス , 【Automatic Indexing@JST】

Author keywords (10)： biomarkers ,  NRF2 (nuclear factor erythroid 2 related factor 2) ,  sulforaphane ,  oltipraz ,  bardoxolone methyl ,  dimethyl fumarate ,  oxidative stress ,  inflammation ,  gene expression ,  carcinogenesis

JST classification (4)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Gene expression  (EC02040Q) ,  Cell physiology in general  (EF02010S) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Substance index (2)： Bardoxolone methyl ,  Fumaric acid dimethyl

Reference (242)：

• Itoh, K.; Chiba, T.; Takahashi, S.; Ishii, T.; Igarashi, K.; Katoh, Y.; Oyake, T.; Hayashi, N.; Satoh, K.; Hatayama, I.; et al. A Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem. Biophys. Res. Commun. 1997, 236, 313-322.
• Gong, P.; Stewart, D.; Hu, B.; Li, N.; Cook, J.; Nel, A.; Alam, J. Activation of the mouse heme oxygenase-1 gene by 15-deoxy-Delta(12,14)-prostaglandin J(2) is mediated by the stress response elements and transcription factor Nrf2. Antioxid. Redox Signal. 2002, 4, 249-257.
• Hayes, J.D.; Dinkova-Kostova, A.T. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Trends Biochem. Sci. 2014, 39, 199-218.
• Wakabayashi, N.; Slocum, S.L.; Skoko, J.J.; Shin, S.; Kensler, T.W. When NRF2 talks, who’s listening? Antioxid. Redox Signal. 2010, 13, 1649-1663.
• Yamamoto, M.; Kensler, T.W.; Motohashi, H. The KEAP1-NRF2 system: A thiol-based sensor-effector apparatus for maintaining redox homeostasis. Physiol. Rev. 2018, 98, 1169-1203.

Terms in the title (4)： 臨床試験 ,  NRF2 ,  バイオマーカー ,  景観