Art

J-GLOBAL ID：202102231179504103   Reference number：21A0580772

Understanding the Redox Biology of Selenium in the Search of Targeted Cancer Therapies

標的癌治療の探索におけるセレンの酸化還元生物学の理解【JST・京大機械翻訳】

Author (6)： Stolwijk Jeffrey M. (Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, IA 52242, USA) ,  Garje Rohan (Department of Internal Medicine, Division of Medical Oncology and Hematology, The University of Iowa Hospital and Clinics-Holden Comprehensive Cancer Center, Iowa City, IA 52242, USA) ,  Sieren Jessica C. (Departments of Radiology and Biomedical Engineering, The University of Iowa, Iowa City, IA 52242, USA) ,  Buettner Garry R. (Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, IA 52242, USA) ,  Buettner Garry R. (Free Radical and Radiation Biology Program, Department of Radiation Oncology, The University of Iowa, Iowa City, IA 52242, USA) ,  Zakharia Yousef (Department of Internal Medicine, Division of Medical Oncology and Hematology, The University of Iowa Hospital and Clinics-Holden Comprehensive Cancer Center, Iowa City, IA 52242, USA)
Material： Antioxidants (Web)
Volume： 9  Issue： 5  Page： 420  Publication year： 2020 
JST Material Number： U7134A  ISSN： 2076-3921  Document type： Article
Article type： 文献レビュー  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Selenium (Se) is an essential ...

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Thesaurus term： *oxidation ,  *selenium ,  cell culture ,  tumor cell ,  protein ,  human(primates) ,  side effect ,  *oxidation-reduction reaction ,  selenium compound ,  selenium deficiency ,  active oxygen ,  dietary supplement
Semi thesaurus term： 微量栄養素 ,  抗酸化剤 ,  *癌治療 , 【Automatic Indexing@JST】

Author keywords (6)： selenium ,  selenomethionine ,  selenoproteins ,  cancer ,  glutathione peroxidases ,  thioredoxin reductases

JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Experimental treatment for tumors  (GE02040Y)

Reference (204)：

• Mills, G.C. Hemoglobin catabolism. I. Glutathione peroxidase, an erythrocyte enzyme which protects hemoglobin from oxidative breakdown. J. Biol. Chem. 1957, 229, 189-197.
• Schwarz, K.; Bieri, J.G.; Briggs, G.M.; Scott, M.L. Prevention of exudative diathesis in chicks by factor 3 and selenium. Proc. Soc. Exp. Biol. Med. 1957, 95, 621-625.
• Schwarz, K.; Foltz, C.M. Selenium as an integral part of factor 3 against dietary necrotic liver degeneration. J. Am. Chem. Soc. 1957, 79, 3292-3293.
• Flohe, L.; Gunzler, W.A.; Schock, H.H. Glutathione peroxidase: A selenoenzyme. FEBS Lett. 1973, 32, 132-134.
• Kraus, R.J.; Foster, S.J.; Ganther, H.E. Identification of selenocysteine in glutathione peroxidase by mass spectroscopy. Biochemistry 1983, 22, 5853-5858.

Terms in the title (7)： 標的 ,  癌治療 ,  探索 ,  セレン ,  酸化還元 ,  生物学 ,  理解